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    Arfgef2 ARF guanine nucleotide exchange factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296380, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arfgef2provided by RGD
    Official Full Name
    ARF guanine nucleotide exchange factor 2provided by RGD
    Primary source
    RGD:631430
    See related
    EnsemblRapid:ENSRNOG00000007485 AllianceGenome:RGD:631430
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Big2
    Summary
    Enables GABA receptor binding activity and myosin binding activity. Involved in exocytosis. Located in several cellular components, including axonemal microtubule; symmetric synapse; and trans-Golgi network. Is active in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and postsynapse. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human ARFGEF2 (ADP ribosylation factor guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 205.5), Adrenal (RPKM 130.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arfgef2 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (175966575..176052715)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (155547504..155633652)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (163570435..163656612)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene tumor protein p53 regulating kinase B Neighboring gene uncharacterized LOC134486207 Neighboring gene chromosome segregation 1 like Neighboring gene staufen double-stranded RNA binding protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The brefeldin A-inhibited guanine nucleotide-exchange protein, BIG2, regulates the constitutive release of TNFR1 exosome-like vesicles. Islam A, et al. J Biol Chem, 2007 Mar 30. PMID 17276987
    2. Association of brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2) with recycling endosomes during transferrin uptake. Shen X, et al. Proc Natl Acad Sci U S A, 2006 Feb 21. PMID 16477018, Free PMC Article
    3. BIG2, a guanine nucleotide exchange factor for ADP-ribosylation factors: its localization to recycling endosomes and implication in the endosome integrity. Shin HW, et al. Mol Biol Cell, 2004 Dec. PMID 15385626, Free PMC Article
    4. Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex. Sheen VL, et al. Nat Genet, 2004 Jan. PMID 14647276
    5. Dominant-negative mutant of BIG2, an ARF-guanine nucleotide exchange factor, specifically affects membrane trafficking from the trans-Golgi network through inhibiting membrane association of AP-1 and GGA coat proteins. Shinotsuka C, et al. Biochem Biophys Res Commun, 2002 Jun 7. PMID 12051703

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. interaction with the GABA(A)receptor beta subunits may play a role in the exocytosis and trafficking of assembled GABA(A) receptors to the cell surface
      Title: The brefeldin A-inhibited GDP/GTP exchange factor 2, a protein involved in vesicular trafficking, interacts with the beta subunits of the GABA receptors.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GABA receptor binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables myosin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase A regulatory subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase A regulatory subunit binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi to plasma membrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endomembrane system organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endomembrane system organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of tumor necrosis factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in receptor recycling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in asymmetric synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axonemal microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule organizing center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule organizing center ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in symmetric synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    brefeldin A-inhibited guanine nucleotide-exchange protein 2
    Names
    ADP ribosylation factor guanine nucleotide exchange factor 2
    ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
    Brefeldin A-inhibited guanine nucleotide-exchange factor 2
    brefeldin A-inhibited GEP 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430231.1 → NP_001417160.1  brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JXH9

    2. NM_181083.3 → NP_851597.2  brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform 1

      See identical proteins and their annotated locations for NP_851597.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q7TSU1
      UniProtKB/TrEMBL
      A6JXH9
      Related
      ENSRNOP00000010054.4, ENSRNOT00000010054.7
      Conserved Domains (5) summary
      PLN03076
      Location:11 → 1718
      PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
      pfam01369
      Location:650 → 834
      Sec7; Sec7 domain
      pfam09324
      Location:1174 → 1255
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:377 → 531
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16213
      Location:28 → 198
      DCB; Dimerization and cyclophilin-binding domain of Mon2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      175966575..176052715
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235640.5 → XP_006235702.1  brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1

      Related
      ENSRNOP00000096461.1, ENSRNOT00000103177.2
      Conserved Domains (5) summary
      PLN03076
      Location:11 → 1717
      PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
      pfam01369
      Location:649 → 833
      Sec7; Sec7 domain
      pfam09324
      Location:1173 → 1254
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:376 → 530
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16213
      Location:28 → 198
      DCB; Dimerization and cyclophilin-binding domain of Mon2

    2. XM_063283411.1 → XP_063139481.1  brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X2

      UniProtKB/TrEMBL
      A6JXH9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TSU1.1 GenPept UniProtKB/Swiss-Prot:Q7TSU1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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