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    Armc10 armadillo repeat containing 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296758, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Armc10provided by RGD
    Official Full Name
    armadillo repeat containing 10provided by RGD
    Primary source
    RGD:1305915
    See related
    EnsemblRapid:ENSRNOG00000012785 AllianceGenome:RGD:1305915
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305915; 2810037c14rik
    Summary
    Predicted to enable DNA binding domain binding activity and p53 binding activity. Predicted to be involved in negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator and positive regulation of growth rate. Predicted to be located in endoplasmic reticulum. Predicted to be active in mitochondrion. Orthologous to human ARMC10 (armadillo repeat containing 10). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 102.8), Kidney (RPKM 95.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Armc10 in Genome Data Viewer
    Location:
    4q11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (14291211..14306799, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (13399004..13414594, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (10004846..10020017, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor 1, pseudogene 3 Neighboring gene N-acyl phosphatidylethanolamine phospholipase D Neighboring gene F-box and leucine-rich repeat protein 13 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene leucine rich repeat containing 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A specific splicing variant of SVH, a novel human armadillo repeat protein, is up-regulated in hepatocellular carcinomas. Huang R, et al. Cancer Res, 2003 Jul 1. PMID 12839973
    2. SVH-B interacts directly with p53 and suppresses the transcriptional activity of p53. Zhou X, et al. FEBS Lett, 2007 Oct 16. PMID 17904127
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of growth rate ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    armadillo repeat-containing protein 10
    Names
    SVH protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106576.2 → NP_001100046.2  armadillo repeat-containing protein 10

      See identical proteins and their annotated locations for NP_001100046.2

      Status: VALIDATED

      Source sequence(s)
      BC079464, CN541016, DY320753
      UniProtKB/Swiss-Prot
      B1WBW4
      UniProtKB/TrEMBL
      A6K5B4
      Related
      ENSRNOP00000042700.4, ENSRNOT00000044020.5
      Conserved Domains (3) summary
      cd00020
      Location:53 → 138
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam04826
      Location:50 → 298
      Arm_2; Armadillo-like
      sd00043
      Location:54 → 87
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      14291211..14306799 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1WBW4.1 GenPept UniProtKB/Swiss-Prot:B1WBW4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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