Ptprn2 protein tyrosine phosphatase, receptor type N2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptprn2provided by RGD
Official Full Name: protein tyrosine phosphatase, receptor type N2provided by RGD
Primary source: RGD:61904
See related: EnsemblRapid:ENSRNOG00000005003 AllianceGenome:RGD:61904
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PTPNE6; R-PTP-N2
Summary: Predicted to enable protein tyrosine phosphatase activity. Involved in negative regulation of GTPase activity. Located in endoplasmic reticulum lumen; secretory granule; and terminal bouton. Is active in synaptic vesicle membrane. Human ortholog(s) of this gene implicated in prediabetes syndrome and type 1 diabetes mellitus. Orthologous to human PTPRN2 (protein tyrosine phosphatase receptor type N2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 258.7) and Adrenal (RPKM 24.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 6q33

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (143582568..144334573)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (137439572..138191575)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (144384773..145133042)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of Ptprn-2 delays the onset of puberty in female rats.
Title: Knockdown of Ptprn-2 delays the onset of puberty in female rats.

Submit: New GeneRIF Correction

General gene information

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Markers

RH142979 (e-PCR)
- UniSTS:232226

AU047288 (e-PCR)
- UniSTS:110656

RH140469 (e-PCR)
- UniSTS:222543

BE120609 (e-PCR)
- UniSTS:247383

AU048803 (e-PCR)
- UniSTS:145253

BF405459 (e-PCR)
- UniSTS:247911

d6rat4 (e-PCR)
- UniSTS:122245

D6Rat1 (e-PCR)
- UniSTS:118945

RH131937 (e-PCR)
- UniSTS:215220

D6Rat215 (e-PCR), detects polymorphism
- UniSTS:228052

RH133268 (e-PCR)
- UniSTS:216551

RH131993 (e-PCR)
- UniSTS:215276

BF396367 (e-PCR)
- UniSTS:245756

D6Got203 (e-PCR)
- UniSTS:112381

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in insulin secretion involved in cellular response to glucose stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in insulin secretion involved in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
involved_in insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in insulin secretion involved in cellular response to glucose stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter secretion	IEA Inferred from Electronic Annotation more info
involved_in neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of secretion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum lumen	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule	ISO Inferred from Sequence Orthology more info
located_in secretory granule membrane	IEA Inferred from Electronic Annotation more info
located_in secretory granule membrane	ISO Inferred from Sequence Orthology more info
located_in secretory granule membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle membrane	EXP Inferred from Experiment more info	PubMed
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: receptor-type tyrosine-protein phosphatase N2

Names: PTP NE-6; phogrin; protein tyrosine phosphatase receptor-type N polypeptide 2

NP_113788.1

EC 3.1.3.48

XP_038967789.1

EC 3.1.3.48

XP_038967790.1

EC 3.1.3.48

XP_038967791.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031600.2 → NP_113788.1 receptor-type tyrosine-protein phosphatase N2 precursor

See identical proteins and their annotated locations for NP_113788.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q63475

UniProtKB/TrEMBL

A6KDL9

Related

ENSRNOP00000110350.1, ENSRNOT00000160214.1

Conserved Domains (4) summary

smart00194
Location:734 → 993

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:761 → 993

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

pfam11548
Location:501 → 586

Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2

pfam14948
Location:58 → 113

RESP18; RESP18 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

143582568..144334573

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039111861.2 → XP_038967789.1 receptor-type tyrosine-protein phosphatase N2 isoform X1

UniProtKB/TrEMBL

A0A8I6AHT8

Related

ENSRNOP00000093030.1, ENSRNOT00000116222.2

Conserved Domains (3) summary

cd14610
Location:738 → 1020

R-PTP-N2; PTP-like domain of receptor-type tyrosine-protein phosphatase N2

pfam11548
Location:520 → 608

Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2

pfam14948
Location:80 → 148

RESP18; RESP18 domain
XM_039111863.2 → XP_038967791.1 receptor-type tyrosine-protein phosphatase N2 isoform X3

Conserved Domains (3) summary

cd14610
Location:670 → 952

R-PTP-N2; PTP-like domain of receptor-type tyrosine-protein phosphatase N2

pfam11548
Location:452 → 540

Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2

pfam14948
Location:80 → 148

RESP18; RESP18 domain
XM_039111862.2 → XP_038967790.1 receptor-type tyrosine-protein phosphatase N2 isoform X2

Related

ENSRNOP00000006942.5, ENSRNOT00000006942.6

Conserved Domains (3) summary

cd14610
Location:699 → 981

R-PTP-N2; PTP-like domain of receptor-type tyrosine-protein phosphatase N2

pfam11548
Location:481 → 569

Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2

pfam14948
Location:41 → 96

RESP18; RESP18 domain