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    Flrt2 fibronectin leucine rich transmembrane protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299236, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Flrt2provided by RGD
    Official Full Name
    fibronectin leucine rich transmembrane protein 2provided by RGD
    Primary source
    RGD:1308574
    See related
    EnsemblRapid:ENSRNOG00000003732 AllianceGenome:RGD:1308574
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable chemorepellent activity and fibroblast growth factor receptor binding activity. Involved in regulation of postsynapse assembly. Is active in glutamatergic synapse and postsynaptic membrane. Orthologous to human FLRT2 (fibronectin leucine rich transmembrane protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 72.3), Kidney (RPKM 70.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Flrt2 in Genome Data Viewer
    Location:
    6q31
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (120507998..120603133)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (114777547..114872688)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (119518459..119613534)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549466 Neighboring gene uncharacterized LOC102549614 Neighboring gene uncharacterized LOC108351288 Neighboring gene uncharacterized LOC134479291 Neighboring gene serpin family B member 5, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. FLRT2 prevents endothelial cell senescence and vascular aging by regulating the ITGB4/mTORC2/p53 signaling pathway. Hwang HJ, et al. JCI Insight, 2024 Apr 8. PMID 38587072, Free PMC Article
    2. A Modular Organization of LRR Protein-Mediated Synaptic Adhesion Defines Synapse Identity. Schroeder A, et al. Neuron, 2018 Jul 25. PMID 29983322
    3. Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development. Haines BP, et al. Dev Biol, 2006 Sep 1. PMID 16872596
    4. The fibronectin leucine-rich repeat transmembrane protein Flrt2 is required in the epicardium to promote heart morphogenesis. Müller PS, et al. Development, 2011 Apr. PMID 21350012, Free PMC Article
    5. FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons. Yamagishi S, et al. EMBO J, 2011 Jun 14. PMID 21673655, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FLRT2 prevents endothelial cell senescence and vascular aging by regulating the ITGB4/mTORC2/p53 signaling pathway.
      Title: FLRT2 prevents endothelial cell senescence and vascular aging by regulating the ITGB4/mTORC2/p53 signaling pathway.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chemorepellent activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fibroblast growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within axon guidance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in basement membrane organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in basement membrane organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell adhesion involved in heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell adhesion involved in heart morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fibroblast growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heart morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell-cell junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat transmembrane protein FLRT2
    Names
    fibronectin-like domain-containing leucine-rich transmembrane protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106750.1 → NP_001100220.1  leucine-rich repeat transmembrane protein FLRT2 precursor

      See identical proteins and their annotated locations for NP_001100220.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473982
      UniProtKB/Swiss-Prot
      D3ZTV3
      Conserved Domains (6) summary
      TIGR00864
      Location:282 → 359
      PCC; polycystin cation channel protein
      smart00013
      Location:35 → 66
      LRRNT; Leucine rich repeat N-terminal domain
      sd00031
      Location:65 → 86
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:90 → 110
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00041
      Location:426 → 494
      fn3; Fibronectin type III domain
      cd21340
      Location:89 → 311
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      120507998..120603133
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112060.2 → XP_038967988.1  leucine-rich repeat transmembrane protein FLRT2 isoform X1

      UniProtKB/Swiss-Prot
      D3ZTV3
      Related
      ENSRNOP00000083901.1, ENSRNOT00000113363.2
      Conserved Domains (6) summary
      TIGR00864
      Location:282 → 359
      PCC; polycystin cation channel protein
      smart00013
      Location:35 → 66
      LRRNT; Leucine rich repeat N-terminal domain
      sd00031
      Location:65 → 86
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:90 → 110
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00041
      Location:426 → 494
      fn3; Fibronectin type III domain
      cd21340
      Location:89 → 311
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    2. XM_063261758.1 → XP_063117828.1  leucine-rich repeat transmembrane protein FLRT2 isoform X1

      UniProtKB/Swiss-Prot
      D3ZTV3
      Related
      ENSRNOP00000079728.1, ENSRNOT00000120043.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZTV3.1 GenPept UniProtKB/Swiss-Prot:D3ZTV3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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