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    Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301011, updated on 9-Dec-2024

    Summary

    Official Symbol
    Uqcrc1provided by RGD
    Official Full Name
    ubiquinol-cytochrome c reductase core protein 1provided by RGD
    Primary source
    RGD:1303314
    See related
    EnsemblRapid:ENSRNOG00000032134 AllianceGenome:RGD:1303314
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin protein ligase binding activity. Involved in response to activity and response to alkaloid. Part of respiratory chain complex III. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human UQCRC1 (ubiquinol-cytochrome c reductase core protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 3760.7), Muscle (RPKM 2441.8) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Uqcrc1 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (118468223..118479968)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (109589735..109601481)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (117679328..117691073)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene transmembrane protein 89 Neighboring gene collagen type VII alpha 1 chain Neighboring gene microRNA 711 Neighboring gene urocortin 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC93712

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within mitochondrial electron transport, ubiquinol to cytochrome c ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to activity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to alkaloid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    part_of respiratory chain complex III IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cytochrome b-c1 complex subunit 1, mitochondrial
    Names
    complex III subunit 1
    core protein I
    ubiquinol-cytochrome c reductase core protein I
    ubiquinol-cytochrome-c reductase complex core protein 1
    NP_001004250.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004250.2NP_001004250.1  cytochrome b-c1 complex subunit 1, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001004250.1

      Status: PROVISIONAL

      Source sequence(s)
      BC078923
      UniProtKB/Swiss-Prot
      Q68FY0
      UniProtKB/TrEMBL
      A6I395
      Related
      ENSRNOP00000044696.2, ENSRNOT00000042114.6
      Conserved Domains (1) summary
      COG0612
      Location:46469
      PqqL; Predicted Zn-dependent peptidase [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      118468223..118479968
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)