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    B4galt4 beta-1,4-galactosyltransferase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303923, updated on 9-Dec-2024

    Summary

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    Official Symbol
    B4galt4provided by RGD
    Official Full Name
    beta-1,4-galactosyltransferase 4provided by RGD
    Primary source
    RGD:1307880
    See related
    EnsemblRapid:ENSRNOG00000003114 AllianceGenome:RGD:1307880
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable N-acetyllactosamine synthase activity. Predicted to be involved in glycosylation; keratan sulfate biosynthetic process; and lactosylceramide biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Orthologous to human B4GALT4 (beta-1,4-galactosyltransferase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 111.8), Uterus (RPKM 60.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See B4galt4 in Genome Data Viewer
    Location:
    11q21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (75501358..75527291, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (61995807..62021751, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (64558006..64584054, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene testis expressed 55 Neighboring gene uroplakin 1B Neighboring gene uncharacterized LOC134481005 Neighboring gene Rho GTPase activating protein 31

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acetyllactosamine synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables N-acetyllactosamine synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables UDP-galactosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables UDP-galactosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables galactosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in keratan sulfate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in keratan sulfate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lactosylceramide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lactosylceramide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    beta-1,4-galactosyltransferase 4
    Names
    N-acetyllactosamine synthase
    UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4
    UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 4
    UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4
    b4Gal-T4
    beta-1,4-GalTase 4
    beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase
    beta4Gal-T4
    lactotriaosylceramide beta-1,4-galactosyltransferase
    nal synthase
    NP_001012018.1
    XP_017453489.1
    XP_063126597.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012018.1 → NP_001012018.1  beta-1,4-galactosyltransferase 4

      See identical proteins and their annotated locations for NP_001012018.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081866
      UniProtKB/Swiss-Prot
      Q66HH1
      UniProtKB/TrEMBL
      A6IR55
      Related
      ENSRNOP00000004289.4, ENSRNOT00000004289.8
      Conserved Domains (1) summary
      cd00899
      Location:122 → 339
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      75501358..75527291 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598000.3 → XP_017453489.1  beta-1,4-galactosyltransferase 4 isoform X1

      UniProtKB/Swiss-Prot
      Q66HH1
      UniProtKB/TrEMBL
      A6IR55
      Conserved Domains (1) summary
      cd00899
      Location:122 → 339
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

    2. XM_063270527.1 → XP_063126597.1  beta-1,4-galactosyltransferase 4 isoform X2

    RNA

    1. XR_005491030.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66HH1.1 GenPept UniProtKB/Swiss-Prot:Q66HH1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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