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    Mmp19 matrix metallopeptidase 19 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304608, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mmp19provided by RGD
    Official Full Name
    matrix metallopeptidase 19provided by RGD
    Primary source
    RGD:1311376
    See related
    EnsemblRapid:ENSRNOG00000006778 AllianceGenome:RGD:1311376
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metalloendopeptidase activity. Involved in female gonad development; response to cAMP; and response to hormone. Predicted to be located in extracellular matrix. Predicted to be active in extracellular space. Orthologous to human MMP19 (matrix metallopeptidase 19). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 168.9), Adrenal (RPKM 110.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mmp19 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (1805732..1814054)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (1221229..1229555)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (3216392..3224202)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene diacylglycerol kinase, alpha Neighboring gene roadblock domain containing 3, pseudogene 1 Neighboring gene PYM homolog 1, exon junction complex associated factor Neighboring gene transmembrane protein 198b Neighboring gene DnaJ heat shock protein family (Hsp40) member C14 Neighboring gene ORMDL sphingolipid biosynthesis regulator 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of matrix metalloproteinase-19 messenger RNA expression in the rat ovary. Jo M, et al. Biol Reprod, 2004 Dec. PMID 15286033
    2. Matrix metalloproteinases are differentially expressed in adipose tissue during obesity and modulate adipocyte differentiation. Chavey C, et al. J Biol Chem, 2003 Apr 4. PMID 12529376
    3. In vivo gene expression revealed by cDNA arrays: the pattern in relapsing-remitting multiple sclerosis patients compared with normal subjects. Ramanathan M, et al. J Neuroimmunol, 2001 Jun 1. PMID 11438176
    4. Diet-induced obesity and reduced skin cancer susceptibility in matrix metalloproteinase 19-deficient mice. Pendás AM, et al. Mol Cell Biol, 2004 Jun. PMID 15169894, Free PMC Article
    5. Biochemical characterization of the catalytic domain of human matrix metalloproteinase 19. Evidence for a role as a potent basement membrane degrading enzyme. Stracke JO, et al. J Biol Chem, 2000 May 19. PMID 10809722

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in luteolysis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in ovarian follicle development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in ovulation from ovarian follicle IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to cAMP IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to hormone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    matrix metalloproteinase-19
    Names
    MMP-19
    matrix metalloproteinase 19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107159.3 → NP_001100629.1  matrix metalloproteinase-19 precursor

      See identical proteins and their annotated locations for NP_001100629.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6KSI7, C0M4B0, F7EUD4
      Related
      ENSRNOP00000008909.4, ENSRNOT00000008909.9
      Conserved Domains (3) summary
      cd00094
      Location:286 → 471
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:105 → 257
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam01471
      Location:27 → 81
      PG_binding_1; Putative peptidoglycan binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      1805732..1814054
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240758.4 → XP_006240820.1  matrix metalloproteinase-19 isoform X1

      Conserved Domains (3) summary
      cd00094
      Location:214 → 399
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:33 → 185
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00413
      Location:32 → 185
      Peptidase_M10; Matrixin

    2. XM_039078969.2 → XP_038934897.1  matrix metalloproteinase-19 isoform X2

      Conserved Domains (3) summary
      cd04278
      Location:105 → 257
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam01471
      Location:27 → 81
      PG_binding_1; Putative peptidoglycan binding domain
      cl02471
      Location:286 → 354
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    Nucleotide Protein Strain
    Heading Accession and Version

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