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    Capn7 calpain 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306260, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Capn7provided by RGD
    Official Full Name
    calpain 7provided by RGD
    Primary source
    RGD:1304855
    See related
    EnsemblRapid:ENSRNOG00000019273 AllianceGenome:RGD:1304855
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable MIT domain binding activity and cysteine-type endopeptidase activity. Predicted to be involved in positive regulation of epithelial cell migration and self proteolysis. Predicted to be located in centrosome and cytosol. Orthologous to human CAPN7 (calpain 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 122.2), Kidney (RPKM 118.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Capn7 in Genome Data Viewer
    Location:
    16p16
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (6552048..6588317)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (6545630..6581908)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (7435541..7472483)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene GDP-mannose 4, 6-dehydratase, pseudogene 1 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene SH3-domain binding protein 5 Neighboring gene uncharacterized LOC134482448 Neighboring gene uncharacterized LOC134482449

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CAPN 7 promotes the migration and invasion of human endometrial stromal cell by regulating matrix metalloproteinase 2 activity. Liu H, et al. Reprod Biol Endocrinol, 2013 Jul 15. PMID 23855590, Free PMC Article
    2. Autolytic activity of human calpain 7 is enhanced by ESCRT-III-related protein IST1 through MIT-MIM interaction. Osako Y, et al. FEBS J, 2010 Nov. PMID 20849418
    3. Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus. Gafni J, et al. J Biol Chem, 2004 May 7. PMID 14981075
    4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124688

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MIT domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium-dependent cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in self proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    calpain-7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030037.1 → NP_001025208.1  calpain-7

      See identical proteins and their annotated locations for NP_001025208.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099770
      UniProtKB/TrEMBL
      E9PU30, Q499T5
      Related
      ENSRNOP00000026323.5, ENSRNOT00000026323.8
      Conserved Domains (4) summary
      smart00720
      Location:687 → 810
      calpain_III; calpain_III domain
      cd00044
      Location:214 → 538
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
      cd02681
      Location:5 → 76
      MIT_calpain7_1; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in the nuclear thiol protease PalBH. The molecular function of the MIT domain is unclear.
      cl00299
      Location:85 → 157
      MIT; domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      6552048..6588317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275347.1 → XP_063131417.1  calpain-7 isoform X3

    2. XM_006252608.5 → XP_006252670.2  calpain-7 isoform X1

      See identical proteins and their annotated locations for XP_006252670.2

      Related
      ENSRNOP00000099853.1, ENSRNOT00000170974.1
      Conserved Domains (3) summary
      smart00720
      Location:643 → 766
      calpain_III; calpain_III domain
      cd00044
      Location:170 → 494
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
      cl00299
      Location:41 → 113
      MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...

    3. XM_039094448.2 → XP_038950376.1  calpain-7 isoform X2

      Conserved Domains (2) summary
      smart00720
      Location:522 → 645
      calpain_III; calpain_III domain
      cd00044
      Location:49 → 373
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

    4. XM_039094447.2 → XP_038950375.1  calpain-7 isoform X2

      Conserved Domains (2) summary
      smart00720
      Location:522 → 645
      calpain_III; calpain_III domain
      cd00044
      Location:49 → 373
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

    5. XM_039094450.2 → XP_038950378.1  calpain-7 isoform X2

      Conserved Domains (2) summary
      smart00720
      Location:522 → 645
      calpain_III; calpain_III domain
      cd00044
      Location:49 → 373
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    Nucleotide Protein Strain
    Heading Accession and Version

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