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    Ripor2 RHO family interacting cell polarization regulator 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306934, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ripor2provided by RGD
    Official Full Name
    RHO family interacting cell polarization regulator 2provided by RGD
    Primary source
    RGD:1306939
    See related
    EnsemblRapid:ENSRNOG00000018804 AllianceGenome:RGD:1306939
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam65b; Ab2-162; RGD1306939
    Summary
    Predicted to enable 14-3-3 protein binding activity and identical protein binding activity. Predicted to be involved in several processes, including negative regulation of T cell activation; positive regulation of cellular component organization; and regulation of leukocyte migration. Located in apical plasma membrane and stereocilium membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 21 and autosomal recessive nonsyndromic deafness 104. Orthologous to human RIPOR2 (RHO family interacting cell polarization regulator 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 497.7), Kidney (RPKM 338.4) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ripor2 in Genome Data Viewer
    Location:
    17p11
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (40751771..40975611, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (40323748..40547482, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (42324594..42549907, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene geminin, DNA replication inhibitor Neighboring gene armadillo-like helical domain containing 2 Neighboring gene uncharacterized LOC102552189 Neighboring gene U6 spliceosomal RNA Neighboring gene cytidine monophospho-N-acetylneuraminic acid hydroxylase Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables 14-3-3 protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ferric iron binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in auditory receptor cell stereocilium organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to chemokine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to chemokine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in muscle organ development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of Rho guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of Rho guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of T cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of T cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of establishment of T cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of establishment of T cell polarity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of protein localization to cell leading edge ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein localization to cell leading edge ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of filopodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of myoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of myoblast fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of myoblast fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neutrophil chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neutrophil extravasation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neutrophil extravasation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of establishment of cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of establishment of cell polarity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sensory perception of sound IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sensory perception of sound ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in filopodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in filopodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in filopodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in stereocilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in stereocilium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in stereocilium membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in stereocilium membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    rho family-interacting cell polarization regulator 2
    Names
    family with sequence similarity 65, member B
    protein FAM65B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014009.3NP_001014031.2  rho family-interacting cell polarization regulator 2

      See identical proteins and their annotated locations for NP_001014031.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      Q7TP54
      Related
      ENSRNOP00000048390.1, ENSRNOT00000048298.3
      Conserved Domains (4) summary
      pfam00210
      Location:11641282
      Ferritin; Ferritin-like domain
      pfam15903
      Location:118529
      PL48; Filopodia upregulated, FAM65
      cl00264
      Location:11601304
      Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins
      cl14615
      Location:9631097
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      40751771..40975611 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017600533.3XP_017456022.1  rho family-interacting cell polarization regulator 2 isoform X6

      UniProtKB/TrEMBL
      A6KLG3
    2. XM_017600530.3XP_017456019.1  rho family-interacting cell polarization regulator 2 isoform X1

      UniProtKB/TrEMBL
      A6KLG4
    3. XM_017600531.3XP_017456020.1  rho family-interacting cell polarization regulator 2 isoform X2

      UniProtKB/TrEMBL
      A6KLG4
    4. XM_063276412.1XP_063132482.1  rho family-interacting cell polarization regulator 2 isoform X7

    5. XM_006253929.5XP_006253991.1  rho family-interacting cell polarization regulator 2 isoform X3

      UniProtKB/TrEMBL
      A6KLG4
      Conserved Domains (3) summary
      pfam15903
      Location:45392
      PL48; Filopodia upregulated, FAM65
      sd00044
      Location:960981
      HEAT; HEAT repeat [structural motif]
      cl14615
      Location:8691003
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    6. XM_063276413.1XP_063132483.1  rho family-interacting cell polarization regulator 2 isoform X8

    7. XM_006253930.3XP_006253992.1  rho family-interacting cell polarization regulator 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y5T3, A6KLG4
      Related
      ENSRNOP00000082516.1, ENSRNOT00000110402.2
      Conserved Domains (3) summary
      pfam15903
      Location:41388
      PL48; Filopodia upregulated, FAM65
      sd00044
      Location:956977
      HEAT; HEAT repeat [structural motif]
      cl14615
      Location:865999
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    8. XM_063276414.1XP_063132484.1  rho family-interacting cell polarization regulator 2 isoform X9

      UniProtKB/TrEMBL
      A0A8I5Y5T3
      Related
      ENSRNOP00000077001.1, ENSRNOT00000117811.2
    9. XM_063276411.1XP_063132481.1  rho family-interacting cell polarization regulator 2 isoform X5

      UniProtKB/TrEMBL
      A0A8I6GLY0
    10. XM_017600535.3XP_017456024.1  rho family-interacting cell polarization regulator 2 isoform X12

      UniProtKB/TrEMBL
      A0A8I6AP27, A6KLG7
      Related
      ENSRNOP00000096012.1, ENSRNOT00000102510.2
    11. XM_017600534.3XP_017456023.1  rho family-interacting cell polarization regulator 2 isoform X10

      UniProtKB/TrEMBL
      A6KLG8
    12. XM_063276416.1XP_063132486.1  rho family-interacting cell polarization regulator 2 isoform X13

      UniProtKB/TrEMBL
      A0A8I5ZX07
      Related
      ENSRNOP00000083444.1, ENSRNOT00000117790.2
    13. XM_063276417.1XP_063132487.1  rho family-interacting cell polarization regulator 2 isoform X14

    14. XM_063276415.1XP_063132485.1  rho family-interacting cell polarization regulator 2 isoform X11

      UniProtKB/TrEMBL
      A0A8I6AQC8
      Related
      ENSRNOP00000096913.1, ENSRNOT00000101796.2