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    Me2 malic enzyme 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307270, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Me2provided by RGD
    Official Full Name
    malic enzyme 2provided by RGD
    Primary source
    RGD:1310321
    See related
    EnsemblRapid:ENSRNOG00000015582 AllianceGenome:RGD:1310321
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable malate dehydrogenase (decarboxylating) (NAD+) activity and malate dehydrogenase (decarboxylating) (NADP+) activity. Predicted to be involved in malate metabolic process; pyruvate metabolic process; and regulation of NADP metabolic process. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in mitochondrial matrix. Orthologous to human ME2 (malic enzyme 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 144.7), Spleen (RPKM 144.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Me2 in Genome Data Viewer
    Location:
    18q12.2
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (69626073..69676218, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (67350833..67400987, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (69737515..69784099, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene EGF-like-domain, multiple 7, pseudogene 1 Neighboring gene elaC ribonuclease Z 1 Neighboring gene uncharacterized LOC134482960 Neighboring gene ribosomal protein L31, pseudogene 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial malic enzyme (ME2) in pancreatic islets of the human, rat and mouse and clonal insulinoma cells. MacDonald MJ, et al. Arch Biochem Biophys, 2009 Aug 15. PMID 19691144, Free PMC Article
    2. Inhibition of miR-214-3p attenuates ferroptosis in myocardial infarction via regulating ME2. Liu F, et al. Biochem Biophys Res Commun, 2023 Jun 18. PMID 37087800
    3. Cardiac glutaminolysis: a maladaptive cancer metabolism pathway in the right ventricle in pulmonary hypertension. Piao L, et al. J Mol Med (Berl), 2013 Oct. PMID 23794090, Free PMC Article
    4. Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. Jiang P, et al. Nature, 2013 Jan 31. PMID 23334421, Free PMC Article
    5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibition of miR-214-3p attenuates ferroptosis in myocardial infarction via regulating ME2.
      Title: Inhibition of miR-214-3p attenuates ferroptosis in myocardial infarction via regulating ME2.
    2. Me2 activity in Islets of Langerhans cells was measured by a spectrophotometric enzyme assay by utilizing the distinct kinetic properties of Me2.
      Title: Mitochondrial malic enzyme (ME2) in pancreatic islets of the human, rat and mouse and clonal insulinoma cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables malate dehydrogenase (decarboxylating) (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables malate dehydrogenase (decarboxylating) (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables malic enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in malate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyruvate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of NADP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NAD-dependent malic enzyme, mitochondrial
    Names
    malic enzyme 2, NAD(+)-dependent, mitochondrial
    NP_001100846.2
    XP_006254985.1
    XP_038952708.1
    XP_063133368.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107376.2 → NP_001100846.2  NAD-dependent malic enzyme, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      BF522605, CB556640, CB794492, CV796911, EV771591, JAXUCZ010000018
      UniProtKB/TrEMBL
      A6KRC6, D3ZJH9
      Related
      ENSRNOP00000041737.3, ENSRNOT00000049759.6
      Conserved Domains (3) summary
      cd05312
      Location:280 → 558
      NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
      PLN03129
      Location:28 → 566
      PLN03129; NADP-dependent malic enzyme; Provisional
      pfam00390
      Location:89 → 270
      malic; Malic enzyme, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      69626073..69676218 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096780.2 → XP_038952708.1  NAD-dependent malic enzyme, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A6KRC6
      Related
      ENSRNOP00000100974.1, ENSRNOT00000163051.1
      Conserved Domains (1) summary
      PLN03129
      Location:35 → 536
      PLN03129; NADP-dependent malic enzyme; Provisional

    2. XM_063277298.1 → XP_063133368.1  NAD-dependent malic enzyme, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A0G2K502, A6KRC6
      Related
      ENSRNOP00000103470.1, ENSRNOT00000173790.1

    3. XM_006254923.5 → XP_006254985.1  NAD-dependent malic enzyme, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A0G2K502, A6KRC6
      Conserved Domains (3) summary
      cd05312
      Location:287 → 565
      NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
      PLN03129
      Location:35 → 573
      PLN03129; NADP-dependent malic enzyme; Provisional
      pfam00390
      Location:96 → 277
      malic; Malic enzyme, N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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