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    Pmvk phosphomevalonate kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310645, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pmvkprovided by RGD
    Official Full Name
    phosphomevalonate kinaseprovided by RGD
    Primary source
    RGD:1310812
    See related
    EnsemblRapid:ENSRNOG00000020696 AllianceGenome:RGD:1310812
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables phosphomevalonate kinase activity. Involved in isopentenyl diphosphate biosynthetic process, mevalonate pathway. Predicted to be located in cytosol and peroxisome. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human PMVK (phosphomevalonate kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 216.0), Brain (RPKM 151.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Pmvk in Genome Data Viewer
    Location:
    2q34
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (177174344..177184076)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (174876586..174886365)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (188784329..188793890)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene pygopus family PHD finger 2 Neighboring gene PBX homeobox interacting protein 1 Neighboring gene potassium calcium-activated channel subfamily N member 3 Neighboring gene uncharacterized LOC134485639 Neighboring gene adenosine deaminase, RNA-specific

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC105660

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphomevalonate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphomevalonate kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphomevalonate kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    NOT located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    phosphomevalonate kinase
    NP_001008353.1
    XP_017446383.1
    XP_038958269.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008352.1NP_001008353.1  phosphomevalonate kinase

      See identical proteins and their annotated locations for NP_001008353.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086349
      UniProtKB/TrEMBL
      A0A8I5ZXC1, F7FJH6, Q5RK24
      Related
      ENSRNOP00000028095.3, ENSRNOT00000028095.7
      Conserved Domains (1) summary
      pfam04275
      Location:14123
      P-mevalo_kinase; Phosphomevalonate kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      177174344..177184076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102341.2XP_038958269.1  phosphomevalonate kinase isoform X1

      Conserved Domains (1) summary
      cl04466
      Location:11135
      P-mevalo_kinase; Phosphomevalonate kinase
    2. XM_017590894.3XP_017446383.1  phosphomevalonate kinase isoform X2

      UniProtKB/TrEMBL
      A6J6G7, A6J6G8
      Conserved Domains (1) summary
      cl04466
      Location:1111
      P-mevalo_kinase; Phosphomevalonate kinase