Snx7 sorting nexin 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Snx7provided by RGD
Full Name: sorting nexin 7provided by RGD
Primary source: RGD:1305480
See related: AllianceGenome:RGD:1305480
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in several processes, including endocytic recycling; macroautophagy; and positive regulation of autophagosome assembly. Predicted to be located in early endosome membrane. Predicted to be active in early endosome and phagophore assembly site. Orthologous to human SNX7 (sorting nexin 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 153.5), Lung (RPKM 110.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q42

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (208528041..208612597, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (205843164..205927737, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (221015302..221099810, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH143548 (e-PCR)
- UniSTS:232794

RH141617 (e-PCR)
- UniSTS:223611

D2Got143 (e-PCR)
- UniSTS:115588

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in piecemeal microautophagy of the nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	ISO Inferred from Sequence Orthology more info
involved_in reticulophagy	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sorting nexin-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012083.1 → NP_001012083.1 sorting nexin-7

See identical proteins and their annotated locations for NP_001012083.1

Status: PROVISIONAL

Source sequence(s)

BC082033

UniProtKB/TrEMBL

F7EXP7, Q66H41

Conserved Domains (2) summary

cd07284
Location:32 → 147

PX_SNX7; The phosphoinositide binding Phox Homology domain of Sorting Nexin 7

cd07666
Location:131 → 373

BAR_SNX7; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

208528041..208612597 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102434.2 → XP_038958362.1 sorting nexin-7 isoform X1

UniProtKB/TrEMBL

F7EXP7

Conserved Domains (2) summary

cd07284
Location:110 → 225

PX_SNX7; The phosphoinositide binding Phox Homology domain of Sorting Nexin 7

cl12013
Location:209 → 389

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature