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    CG12773 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31082, updated on 9-Dec-2024

    Summary

    Official Symbol
    CG12773provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024365
    Locus tag
    Dmel_CG12773
    See related
    AllianceGenome:FB:FBgn0024365
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG12773; EG:8D8.3
    Summary
    Predicted to enable amino acid transmembrane transporter activity and potassium:chloride symporter activity. Predicted to be involved in several processes, including chloride ion homeostasis; monoatomic ion transmembrane transport; and potassium ion homeostasis. Predicted to be located in membrane. Is expressed in several structures, including adult midgut; anterior-posterior subdivision of organism; embryonic/larval gut; foregut anlage; and mesoderm. Orthologous to human SLC12A8 (solute carrier family 12 member 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See CG12773 in Genome Data Viewer
    Location:
    1F4-1F4; 1-0.1 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1349623..1353981, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1243656..1248014, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene N(alpha)-acetyltransferase 30 A Neighboring gene mitochondrial poly(A) polymerase Neighboring gene Tetraspanin 2A Neighboring gene uncharacterized protein Neighboring gene pan gu

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables amino acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables chloride:monoatomic cation symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables potassium:chloride symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in amino acid transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in cell volume homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chloride ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in potassium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    uncharacterized protein
    Names
    CG12773-PA
    CG12773-PB
    CG12773-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1349623..1353981 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297844.1NP_001284773.1  uncharacterized protein Dmel_CG12773, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284773.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O46100
      Conserved Domains (1) summary
      TIGR00930
      Location:88456
      2a30; K-Cl cotransporter
    2. NM_001272202.1NP_001259131.1  uncharacterized protein Dmel_CG12773, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259131.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDG9
      Conserved Domains (1) summary
      TIGR00930
      Location:35455
      2a30; K-Cl cotransporter
    3. NM_130549.3NP_569905.1  uncharacterized protein Dmel_CG12773, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569905.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O46100
      Related
      FBpp0070226
      Conserved Domains (1) summary
      TIGR00930
      Location:88456
      2a30; K-Cl cotransporter