Xirp2 xin actin-binding repeat containing 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Xirp2provided by RGD
Official Full Name: xin actin-binding repeat containing 2provided by RGD
Primary source: RGD:1302980
See related: EnsemblRapid:ENSRNOG00000034258 AllianceGenome:RGD:1302980
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: LACS; Cmya3
Summary: Predicted to enable actin filament binding activity and alpha-actinin binding activity. Predicted to be involved in actin filament organization and regulation of actin filament organization. Predicted to act upstream of or within cardiac muscle tissue morphogenesis; cell-cell junction organization; and ventricular septum development. Predicted to be located in Z disc. Predicted to colocalize with focal adhesion and stress fiber. Human ortholog(s) of this gene implicated in depressive disorder. Orthologous to human XIRP2 (xin actin binding repeat containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 2978.6) and Heart (RPKM 624.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 3q21

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (72534175..72621056)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (52126213..52213094)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (53563207..53658113)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2Jcs24 (e-PCR), detects polymorphism
- UniSTS:142311

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables alpha-actinin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cardiac muscle tissue morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-cell junction organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin filament organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within ventricular septum development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
colocalizes_with focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
colocalizes_with stress fiber	IBA Inferred from Biological aspect of Ancestor more info
located_in stress fiber	IEA Inferred from Electronic Annotation more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: xin actin-binding repeat-containing protein 2

Names: L-NAME induced actin cytoskeletal protein; beta-xin; cardiomyopathy associated 3; cardiomyopathy-associated protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201989.2 → NP_973718.2 xin actin-binding repeat-containing protein 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q71LX6

UniProtKB/TrEMBL

A0A8I6ABN9, F1LMC2

Related

ENSRNOP00000048045.2, ENSRNOT00000048300.5