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    kz kurz [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31205, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kzprovided by FlyBase
    Official Full Name
    kurzprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001330
    Locus tag
    Dmel_CG3228
    See related
    AllianceGenome:FB:FBgn0001330
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3228; Dmel\CG3228; EG:30B8.2; l(1)2Eb; l(1)N4; l67; N1; N8
    Summary
    Predicted to enable RNA binding activity and RNA helicase activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be active in nucleolus. Is expressed in ovary. Human ortholog(s) of this gene implicated in 46,XY sex reversal. Orthologous to human DHX37 (DEAH-box helicase 37). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    2F1-2F1; 1-0.9 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2237858..2242035, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2131891..2136068, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Vinculin Neighboring gene uncharacterized protein Neighboring gene pecanex Neighboring gene female sterile (1) K10 Neighboring gene Odorant receptor 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The kurz locus of Drosophila melanogaster shares conserved motifs with a family of yeast ATP dependent splicing factors. Tirronen M, et al. Nucleic Acids Res, 1992 Apr 11. PMID 1579473, Free PMC Article
    2. Molecular genetics of pecanex, a maternal-effect neurogenic locus of Drosophila melanogaster that potentially encodes a large transmembrane protein. LaBonne SG, et al. Dev Biol, 1989 Nov. PMID 2478400
    3. Oocyte-specific transcription of fs(1)K10: a Drosophila gene affecting dorsal-ventral developmental polarity. Haenlin M, et al. EMBO J, 1987 Mar. PMID 16453754, Free PMC Article
    4. A 43 kilobase cosmid P transposon rescues the fs(1)K10 morphogenetic locus and three adjacent Drosophila developmental mutants. Haenlin M, et al. Cell, 1985 Apr. PMID 2985265
    5. Position-effect variegation in Drosophila melanogaster X chromosome inversion with a breakpoint in a satellite block and its suppression in a secondary rearrangement. Tolchkov EV, et al. Chromosoma, 1997 Dec. PMID 9426284

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kurz
    Names
    CG3228-PA
    CG3228-PB
    kz-PA
    kz-PB
    NP_001284815.1
    NP_476591.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2237858..2242035 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057243.4 → NP_476591.1  kurz, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476591.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46072
      UniProtKB/TrEMBL
      Q6NR37, X2JCE0
      Related
      FBpp0070403
      Conserved Domains (6) summary
      smart00490
      Location:619 → 704
      HELICc; helicase superfamily c-terminal domain
      smart00847
      Location:774 → 859
      HA2; Helicase associated domain (HA2) Add an annotation
      COG1643
      Location:237 → 1058
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd00046
      Location:279 → 418
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam07717
      Location:915 → 1039
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
      cl21455
      Location:369 → 500
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001297886.1 → NP_001284815.1  kurz, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284815.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46072
      UniProtKB/TrEMBL
      Q6NR37, X2JCE0
      Conserved Domains (6) summary
      smart00490
      Location:619 → 704
      HELICc; helicase superfamily c-terminal domain
      smart00847
      Location:774 → 859
      HA2; Helicase associated domain (HA2) Add an annotation
      COG1643
      Location:237 → 1058
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd00046
      Location:279 → 418
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam07717
      Location:915 → 1039
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
      cl21455
      Location:369 → 500
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O46072.1 O46072
    Q6NR37 Q6NR37
    Q9NFN0 Q9NFN0
    X2JCE0 X2JCE0

    Gene LinkOut

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