Mms22l MMS22-like, DNA repair protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mms22lprovided by RGD
Official Full Name: MMS22-like, DNA repair proteinprovided by RGD
Primary source: RGD:1304693
See related: EnsemblRapid:ENSRNOG00000006996 AllianceGenome:RGD:1304693
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1304693
Summary: Predicted to enable single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination; protein localization to chromatin; and replication fork processing. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of FACT complex and MCM complex. Predicted to be active in nuclear replication fork and site of double-strand break. Orthologous to human MMS22L (MMS22 like, DNA repair protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 87.6), Spleen (RPKM 87.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q21

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (42994382..43110371)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (38197707..38313745)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (38844502..38960989)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH137337 (e-PCR)
- UniSTS:219425

AU026369 (e-PCR)
- UniSTS:114348

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in protein localization to chromatin	ISO Inferred from Sequence Orthology more info
involved_in replication fork processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in replication fork processing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of FACT complex	ISO Inferred from Sequence Orthology more info
part_of MCM complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nuclear replication fork	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nuclear replication fork	ISO Inferred from Sequence Orthology more info
located_in nuclear replication fork	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in site of DNA damage	ISO Inferred from Sequence Orthology more info
is_active_in site of double-strand break	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein MMS22-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135780.1 → NP_001129252.1 protein MMS22-like

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

D3ZS39

Related

ENSRNOP00000009545.5, ENSRNOT00000009545.8

Conserved Domains (2) summary

pfam14910
Location:26 → 729

MMS22L_N; S-phase genomic integrity recombination mediator, N-terminal

pfam14911
Location:848 → 1224

MMS22L_C; S-phase genomic integrity recombination mediator, C-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

42994382..43110371

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109818.2 → XP_038965746.1 protein MMS22-like isoform X1

Conserved Domains (2) summary

pfam14910
Location:26 → 729

MMS22L_N; S-phase genomic integrity recombination mediator, N-terminal

pfam14911
Location:848 → 1072

MMS22L_C; S-phase genomic integrity recombination mediator, C-terminal
XM_063287584.1 → XP_063143654.1 protein MMS22-like isoform X2