Dnai4 dynein axonemal intermediate chain 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dnai4provided by RGD
Official Full Name: dynein axonemal intermediate chain 4provided by RGD
Primary source: RGD:1311027
See related: EnsemblRapid:ENSRNOG00000006999 AllianceGenome:RGD:1311027
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Wdr78; RGD1311027
Summary: Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in axonemal dynein complex assembly and cilium movement. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in axoneme; dynein axonemal particle; and motile cilium. Predicted to be part of axonemal dynein complex. Orthologous to human DNAI4 (dynein axonemal intermediate chain 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 137.3), Thymus (RPKM 89.7) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q33

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (123016480..123105283, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (117787398..117876216, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (122551370..122642161, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

AU049090 (e-PCR)
- UniSTS:145538

RH138978 (e-PCR)
- UniSTS:221064

BF388268 (e-PCR)
- UniSTS:244882

d5mit6 (e-PCR)
- UniSTS:122070

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dynein heavy chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein light chain binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in axonemal dynein complex assembly	IEA Inferred from Electronic Annotation more info
involved_in axonemal dynein complex assembly	ISO Inferred from Sequence Orthology more info
involved_in axonemal dynein complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in cilium movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium movement	IEA Inferred from Electronic Annotation more info
involved_in cilium movement	ISO Inferred from Sequence Orthology more info
involved_in cilium movement	ISS Inferred from Sequence or Structural Similarity more info
involved_in hematopoietic progenitor cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of axonemal dynein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of axonemal dynein complex	IEA Inferred from Electronic Annotation more info
part_of axonemal dynein complex	ISO Inferred from Sequence Orthology more info
part_of axonemal dynein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in axoneme	ISO Inferred from Sequence Orthology more info
located_in axoneme	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in dynein axonemal particle	IEA Inferred from Electronic Annotation more info
located_in dynein axonemal particle	ISS Inferred from Sequence or Structural Similarity more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info
located_in motile cilium	ISO Inferred from Sequence Orthology more info
located_in motile cilium	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: dynein axonemal intermediate chain 4

Names: WD repeat domain 78; WD repeat-containing protein 78; dynein intermediate chain 4, axonemal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024786.2 → NP_001019957.1 dynein axonemal intermediate chain 4

See identical proteins and their annotated locations for NP_001019957.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q4V8G4, Q5XIP5

UniProtKB/TrEMBL

A0A8L2QPC1

Related

ENSRNOP00000089481.2, ENSRNOT00000115287.2

Conserved Domains (3) summary

COG2319
Location:443 → 781

WD40; WD40 repeat [General function prediction only]

sd00039
Location:497 → 541

7WD40; WD40 repeat [structural motif]

cl02567
Location:496 → 778

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

123016480..123105283 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063287692.1 → XP_063143762.1 dynein axonemal intermediate chain 4 isoform X4

UniProtKB/TrEMBL

A0A8I6B2X4, A0A8L2QPC1
XM_063287690.1 → XP_063143760.1 dynein axonemal intermediate chain 4 isoform X1

UniProtKB/TrEMBL

A0A8L2QPC1

Related

ENSRNOP00000100351.1, ENSRNOT00000127153.1
XM_063287691.1 → XP_063143761.1 dynein axonemal intermediate chain 4 isoform X2

UniProtKB/TrEMBL

A0A8L2QPC1

Related

ENSRNOP00000106569.1, ENSRNOT00000129945.1
XM_008763872.3 → XP_008762094.1 dynein axonemal intermediate chain 4 isoform X3

UniProtKB/TrEMBL

A0A8L2QPC1

Related

ENSRNOP00000095528.2, ENSRNOT00000117003.2

Conserved Domains (3) summary

COG2319
Location:443 → 764

WD40; WD40 repeat [General function prediction only]

sd00039
Location:498 → 541

7WD40; WD40 repeat [structural motif]

cl02567
Location:496 → 747

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_039109947.2 → XP_038965875.1 dynein axonemal intermediate chain 4 isoform X5

Conserved Domains (2) summary

COG2319
Location:114 → 454

WD40; WD40 repeat [General function prediction only]

sd00039
Location:168 → 212

7WD40; WD40 repeat [structural motif]