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    Nol9 nucleolar protein 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313744, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nol9provided by RGD
    Official Full Name
    nucleolar protein 9provided by RGD
    Primary source
    RGD:1566167
    See related
    EnsemblRapid:ENSRNOG00000010109 AllianceGenome:RGD:1566167
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity. Predicted to be involved in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in intermediate filament cytoskeleton and nucleolus. Predicted to be active in nucleus. Orthologous to human NOL9 (nucleolar protein 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 67.7), Spleen (RPKM 66.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nol9 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (167829249..167849364)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (162546522..162566625)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (169213076..169233173)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 48 Neighboring gene taste 1 receptor member 1 Neighboring gene pleckstrin homology and RhoGEF domain containing G5 Neighboring gene TNF receptor superfamily member 25

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Nol9 is a novel polynucleotide 5'-kinase involved in ribosomal RNA processing. Heindl K, et al. EMBO J, 2010 Dec 15. PMID 21063389, Free PMC Article
    2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables polynucleotide 5'-hydroxyl-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of 5.8S rRNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in intermediate filament cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    polynucleotide 5'-hydroxyl-kinase NOL9
    NP_001386164.1
    XP_038967289.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399235.1 → NP_001386164.1  polynucleotide 5'-hydroxyl-kinase NOL9

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6IUG5, G3V7B0
      Conserved Domains (1) summary
      pfam16575
      Location:322 → 482
      CLP1_P; mRNA cleavage and polyadenylation factor CLP1 P-loop

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      167829249..167849364
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111361.2 → XP_038967289.1  polynucleotide 5'-hydroxyl-kinase NOL9 isoform X1

      UniProtKB/TrEMBL
      A0A8I5YBW7, G3V7B0
      Related
      ENSRNOP00000076785.1, ENSRNOT00000112748.2
      Conserved Domains (1) summary
      pfam16575
      Location:323 → 483
      CLP1_P; mRNA cleavage and polyadenylation factor CLP1 P-loop

    RNA

    1. XR_005505136.2 RNA Sequence

    2. XR_005505135.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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