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    Flvcr2 FLVCR choline and putative heme transporter 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314323, updated on 27-Nov-2024

    Summary

    Official Symbol
    Flvcr2provided by RGD
    Official Full Name
    FLVCR choline and putative heme transporter 2provided by RGD
    Primary source
    RGD:735098
    See related
    EnsemblRapid:ENSRNOG00000008754 AllianceGenome:RGD:735098
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable heme binding activity; heme transmembrane transporter activity; and organic cation transmembrane transporter activity. Predicted to be involved in choline transport; heme export; and transport across blood-brain barrier. Predicted to act upstream of or within several processes, including brain development; endothelial tip cell fate specification; and in utero embryonic development. Predicted to be located in endoplasmic reticulum membrane and mitochondrial membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Orthologous to human FLVCR2 (FLVCR choline and putative heme transporter 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 155.1), Adrenal (RPKM 142.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Flvcr2 in Genome Data Viewer
    Location:
    6q31
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (111139352..111203345)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (105408355..105472355)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (109617348..109681495)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene Jun dimerization protein 2 Neighboring gene uncharacterized LOC108351275 Neighboring gene basic leucine zipper ATF-like transcription factor Neighboring gene uncharacterized LOC120103579 Neighboring gene ergosterol biosynthesis 28 homolog Neighboring gene tubulin tyrosine ligase like 5 Neighboring gene uncharacterized LOC134479235

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Clone Names

    • MGC124539

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables choline binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables choline transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables choline transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables choline transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ethanolamine transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ethanolamine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ethanolamine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables heme transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables heme transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables heme transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables heme transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within brain development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in choline transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within choline transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in choline transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in choline transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within endothelial tip cell fate specification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ethanolamine transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heme export IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in heme transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within transport across blood-brain barrier ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transport across blood-brain barrier ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transport across blood-brain barrier ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    choline/ethanolamine transporter FLVCR2
    Names
    CCT
    FLVCR heme transporter 2
    calcium-chelate transporter
    feline leukemia virus subgroup C cellular receptor family, member 2
    feline leukemia virus subgroup C receptor-related protein 2
    heme transporter FLVCR2
    transporter

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199109.3NP_954540.3  choline/ethanolamine transporter FLVCR2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      P60815
      UniProtKB/TrEMBL
      A6JE38, F1LSF8, Q3T1I6
      Related
      ENSRNOP00000011599.7, ENSRNOT00000011599.8
      Conserved Domains (1) summary
      cl28910
      Location:100505
      MFS; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      111139352..111203345
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)