SPR Sex peptide receptor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: SPRprovided by FlyBase
Official Full Name: Sex peptide receptorprovided by FlyBase
Primary source: FLYBASE:FBgn0029768
Locus tag: Dmel_CG16752
See related: AllianceGenome:FB:FBgn0029768
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12731; CG16752; Dmel\CG16752; DrmSPR; SP-R; spr; Spr
Summary: Enables G protein-coupled peptide receptor activity. Involved in G protein-coupled receptor signaling pathway; negative regulation of female receptivity, post-mating; and regulation of egg-laying behavior. Located in plasma membrane. Is expressed in adult brain; adult cervical connective; epithelial tube; ganglia; and uterus. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 4F11-5A1; 1-11 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (5446656..5494012)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (5340689..5388045)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Decoupled evolution of the Sex Peptide gene family and Sex Peptide Receptor in Drosophilidae.
Title: Decoupled evolution of the Sex Peptide gene family and Sex Peptide Receptor in Drosophilidae.
Molecular evolution of the sex peptide network in Drosophila.
Title: Molecular evolution of the sex peptide network in Drosophila.
Drosophila melanogaster sex peptide regulates mated female midgut morphology and physiology.
Title: Drosophila melanogaster sex peptide regulates mated female midgut morphology and physiology.
Molecular characterization of ligand selectivity of the sex peptide receptors of Drosophila melanogaster and Aedes aegypti.
Title: Molecular characterization of ligand selectivity of the sex peptide receptors of Drosophila melanogaster and Aedes aegypti.
sex peptide enhances memory by acting on a single pair of serotonergic brain neurons, in which activation of the sex peptide receptor stimulates the cyclic adenosine monophosphate/protein kinase A pathway.
Title: A sperm peptide enhances long-term memory in female Drosophila.
Study describes for the first time patterns of mating frequency in Drosophila melanogaster SPR- (sex-peptide-receptor is absent in females) and control groups, showing that SPR- females are on average more polyandrous. These results are not explained by the reduced fecundity of SPR- females, suggesting that the observed differences in sexual selection on males are caused by the elevated polyandry of SPR- females.
Title: Sex peptide receptor-regulated polyandry modulates the balance of pre- and post-copulatory sexual selection in Drosophila.
Data show that female sleep is reduced by male-derived sex Peptide (SP) SP acting through the canonical sex peptide receptor (SPR) within the same neurons responsible for altering other postmating responses (PMRs).
Title: Changes in Female Drosophila Sleep following Mating Are Mediated by SPSN-SAG Neurons.
Results suggested that the SP/SPR-mediated post-mating responses was established in the lineage of the D. melanogaster species group.
Title: Evolution of sex-peptide in Drosophila.
SPR peptide modulates female chemosensory processing upon mating in Drosophila.
Title: Neuropeptides Modulate Female Chemosensory Processing upon Mating in Drosophila.
important in stabilizing sleep in both males and females
Title: A homeostatic sleep-stabilizing pathway in Drosophila composed of the sex peptide receptor and its ligand, the myoinhibitory peptide.

Submit: New GeneRIF Correction See all GeneRIFs (14)

General gene information

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Markers

Dm1896 (e-PCR)
- UniSTS:27803

Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 5481114-5485000 mobile_element_type = transposon:I{}62

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled peptide receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled peptide receptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of female receptivity, post-mating	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Sex peptide receptor

Names: CG16752-PA; CG16752-PB; CG16752-PC; CG16752-PD; SP receptor; SPR-PA; SPR-PB; SPR-PC; SPR-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

5446656..5494012

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001382034.1 → NP_001368972.1 Sex peptide receptor, isoform D [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A6H2EEN9

Conserved Domains (1) summary

cd14978
Location:90 → 400

7tmA_FMRFamide_R-like; FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_131997.2 → NP_572225.1 Sex peptide receptor, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_572225.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8SWR3, Q9W4B9

Related

FBpp0070744

Conserved Domains (2) summary

pfam00001
Location:107 → 389

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:97 → 404

7tm_4; Olfactory receptor
NM_001297964.1 → NP_001284893.1 Sex peptide receptor, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284893.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8SWR3, Q9W4B9

Conserved Domains (2) summary

pfam00001
Location:107 → 389

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:97 → 404

7tm_4; Olfactory receptor
NM_001297963.1 → NP_001284892.1 Sex peptide receptor, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284892.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8SWR3, Q9W4B9

Conserved Domains (2) summary

pfam00001
Location:107 → 389

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:97 → 404

7tm_4; Olfactory receptor