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    Abtb3 ankyrin repeat and BTB domain containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314675, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Abtb3provided by RGD
    Official Full Name
    ankyrin repeat and BTB domain containing 3provided by RGD
    Primary source
    RGD:1308647
    See related
    EnsemblRapid:ENSRNOG00000005758 AllianceGenome:RGD:1308647
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Btbd11
    Summary
    Predicted to enable PDZ domain binding activity. Predicted to act upstream of or within exploration behavior; glutamatergic synaptic transmission; and protein stabilization. Predicted to be located in glutamatergic synapse. Orthologous to human ABTB3 (ankyrin repeat and BTB domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 39.6), Adrenal (RPKM 37.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Abtb3 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (19922883..20199740, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (18035151..18310718, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (24041194..24314418, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene PR/SET domain 4 Neighboring gene PWP1 homolog, endonuclein Neighboring gene Y box binding protein 1, pseudogene 21 Neighboring gene uncharacterized LOC134479646 Neighboring gene sialic acid synthase-like Neighboring gene cryptochrome circadian regulator 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TGF-β/Smad2/3 signaling directly regulates several miRNAs in mouse ES cells and early embryos. Redshaw N, et al. PLoS One, 2013. PMID 23390484, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within exploration behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and BTB/POZ domain-containing protein BTBD11; ankyrin repeat and BTB/POZ domain-containing protein 3
    Names
    BTB (POZ) domain containing 11
    BTB domain containing 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432632.1 → NP_001419561.1  ankyrin repeat and BTB/POZ domain-containing protein BTBD11 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      D4AC89

    2. NM_001432634.1 → NP_001419563.1  ankyrin repeat and BTB/POZ domain-containing protein BTBD11 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6AJE8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      19922883..20199740 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264584.1 → XP_063120654.1  ankyrin repeat and BTB/POZ domain-containing protein 3 isoform X4

    2. XM_063264583.1 → XP_063120653.1  ankyrin repeat and BTB/POZ domain-containing protein 3 isoform X2

      UniProtKB/TrEMBL
      D3Z9Y5
      Related
      ENSRNOP00000008596.6, ENSRNOT00000008596.9

    3. XM_039080070.2 → XP_038935998.1  ankyrin repeat and BTB/POZ domain-containing protein 3 isoform X3

      Conserved Domains (5) summary
      COG5262
      Location:192 → 248
      HTA1; Histone H2A [Chromatin structure and dynamics]
      sd00045
      Location:615 → 656
      ANK; ANK repeat [structural motif]
      cd18351
      Location:789 → 919
      BTB_POZ_BTBD11; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11)
      cd18527
      Location:912 → 994
      BACK_BTBD11; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 11 (BTBD11)
      pfam12796
      Location:589 → 685
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_039080069.2 → XP_038935997.1  ankyrin repeat and BTB/POZ domain-containing protein 3 isoform X1

      Related
      ENSRNOP00000045550.6, ENSRNOT00000044331.8
      Conserved Domains (5) summary
      COG5262
      Location:192 → 248
      HTA1; Histone H2A [Chromatin structure and dynamics]
      sd00045
      Location:615 → 656
      ANK; ANK repeat [structural motif]
      cd18351
      Location:908 → 1038
      BTB_POZ_BTBD11; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11)
      cd18527
      Location:1031 → 1113
      BACK_BTBD11; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 11 (BTBD11)
      pfam12796
      Location:617 → 723
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_063264587.1 → XP_063120657.1  ankyrin repeat and BTB/POZ domain-containing protein 3 isoform X7

    6. XM_063264585.1 → XP_063120655.1  ankyrin repeat and BTB/POZ domain-containing protein 3 isoform X5

    7. XM_063264588.1 → XP_063120658.1  ankyrin repeat and BTB/POZ domain-containing protein 3 isoform X8

    8. XM_039080071.2 → XP_038935999.1  ankyrin repeat and BTB/POZ domain-containing protein 3 isoform X6

      Conserved Domains (5) summary
      sd00045
      Location:134 → 175
      ANK; ANK repeat [structural motif]
      cd18351
      Location:427 → 557
      BTB_POZ_BTBD11; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11)
      cd18527
      Location:550 → 632
      BACK_BTBD11; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 11 (BTBD11)
      pfam13637
      Location:218 → 279
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:136 → 242
      Ank_2; Ankyrin repeats (3 copies)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108078.1: Suppressed sequence

      Description
      NM_001108078.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: BTBD11 (GeneID:121551).
    Nucleotide Protein Strain
    Heading Accession and Version

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