fz4 frizzled 4 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: fz4provided by FlyBase
Official Full Name: frizzled 4provided by FlyBase
Primary source: FLYBASE:FBgn0027342
Locus tag: Dmel_CG4626
See related: AllianceGenome:FB:FBgn0027342
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0170980.10; anon-WO0170980.11; CG4626; Dfz4; DFz4; Dm Fz4; Dmel\CG4626; Fz4
Summary: Enables Wnt-protein binding activity. Predicted to be involved in canonical Wnt signaling pathway and non-canonical Wnt signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including foregut primordium; larval ventral nerve cord; mesoderm; presumptive embryonic/larval central nervous system; and ventral midline of embryo. Human ortholog(s) of this gene implicated in exudative vitreoretinopathy 1. Orthologous to human FZD4 (frizzled class receptor 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (7106272..7110321, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (7000305..7004354, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt-protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

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