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    Corp Companion of reaper [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31764, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Corpprovided by FlyBase
    Official Full Name
    Companion of reaperprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030028
    Locus tag
    Dmel_CG10965
    See related
    AllianceGenome:FB:FBgn0030028
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10965; corp; Dmel\CG10965
    Summary
    Enables p53 binding activity. Involved in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Is expressed in organism; salivary gland; and yolk nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Corp in Genome Data Viewer
    Location:
    7E1-7E1; 1-23 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8269898..8271409, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8163931..8165442, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Thioredoxin reductase 1 Neighboring gene sniffer Neighboring gene NADH dehydrogenase (ubiquinone) 75 kDa subunit Neighboring gene uncharacterized protein Neighboring gene nicotinic Acetylcholine Receptor alpha3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43695

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Towards reconstructing the dipteran demise of an ancient essential gene: E3 ubiquitin ligase Murine double minute. Jasti N, et al. Dev Genes Evol, 2020 Jul. PMID 32623522
    2. Corp Regulates P53 in Drosophila melanogaster via a Negative Feedback Loop. Chakraborty R, et al. PLoS Genet, 2015 Jul. PMID 26230084, Free PMC Article
    3. Programmed cell death: Superman meets Dr Death. Meier P, et al. Nat Cell Biol, 2003 Dec. PMID 14647296
    4. Eiger/TNFα-mediated Dilp8 and ROS production coordinate intra-organ growth in Drosophila. Sanchez JA, et al. PLoS Genet, 2019 Aug. PMID 31425511, Free PMC Article
    5. Fork head controls the timing and tissue selectivity of steroid-induced developmental cell death. Cao C, et al. J Cell Biol, 2007 Mar 12. PMID 17339378, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables p53 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    companion of reaper
    Names
    CG10965-PA
    CG10965-PB
    Corp-PA
    Corp-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      8269898..8271409 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258649.2 → NP_001245578.1  companion of reaper, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245578.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3G9

    2. NM_132240.3 → NP_572468.1  companion of reaper, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572468.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3G9
      Related
      FBpp0071127
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W3G9 Q9W3G9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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