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    CATHL6 cathelicidin 6 [ Bos taurus (domestic cattle) ]

    Gene ID: 317651, updated on 29-Jan-2025

    Summary

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    Gene symbol
    CATHL6
    Gene description
    cathelicidin 6
    See related
    BGD:BT10698; Ensembl:ENSBTAG00000066471
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
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    Genomic context

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    See CATHL6 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (51663351..51665275, complement)

    Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene cathelicidin 2 Neighboring gene cathelicidin-4 Neighboring gene cathelicidin 5 Neighboring gene cell division cycle 25A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Brief Note :Variability in the cathelicidin 6 (CATHL-6) gene in Tianzhu white yak from Tibetan area in China. E GX, et al. Genet Mol Res, 2015 Apr 10. PMID 25966077
    2. Design of nontoxic analogues of cathelicidin-derived bovine antimicrobial peptide BMAP-27: the role of leucine as well as phenylalanine zipper sequences in determining its toxicity. Ahmad A, et al. Biochemistry, 2009 Nov 24. PMID 19845398
    3. Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities. Skerlavaj B, et al. J Biol Chem, 1996 Nov 8. PMID 8910461
    4. Sequence analysis and polymorphism discovery in 4 members of the bovine cathelicidin gene family. Gillenwaters EN, et al. J Hered, 2009 Mar-Apr. PMID 19136450
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that the total length of the aligned Yak cathelicidin 6 (CATHL-6) sequences was 1923 bp, including six single nucleotide polymorphisms and one indel.
      Title: Brief Note :Variability in the cathelicidin 6 (CATHL-6) gene in Tianzhu white yak from Tibetan area in China.
    2. Not only a leucine zipper but also a phenylalanine zipper sequence plays an important role in maintaining the assembly of BMAP-27 on mammalian cells and the cytotoxic activity against them.
      Title: Design of nontoxic analogues of cathelicidin-derived bovine antimicrobial peptide BMAP-27: the role of leucine as well as phenylalanine zipper sequences in determining its toxicity.
    3. Characterization of single nucleotide polymorphisms (SNPs) and insertion-deletion (indel) polymorphisms within the bovine CATHL gene family.
      Title: Sequence analysis and polymorphism discovery in 4 members of the bovine cathelicidin gene family.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables lipopolysaccharide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cathelicidin-6
    Names
    antibacterial peptide BMAP-27
    antimicrobial peptide BMAP-27
    myeloid antibacterial peptide 27

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174832.3 → NP_777257.1  cathelicidin-6 precursor

      See identical proteins and their annotated locations for NP_777257.1

      Status: PROVISIONAL

      Source sequence(s)
      X97608
      UniProtKB/Swiss-Prot
      B9UKM5, P54228
      UniProtKB/TrEMBL
      B9UKM7
      Related
      ENSBTAP00070049628.1, ENSBTAT00070081950.1
      Conserved Domains (1) summary
      pfam00666
      Location:31 → 98
      Cathelicidins; Cathelicidin

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      51663351..51665275 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54228.1 GenPept UniProtKB/Swiss-Prot:P54228

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials