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    Dpep2 dipeptidase 2 [ Mus musculus (house mouse) ]

    Gene ID: 319446, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dpep2provided by MGI
    Official Full Name
    dipeptidase 2provided by MGI
    Primary source
    MGI:MGI:2442042
    See related
    Ensembl:ENSMUSG00000053687 Ensembl:ENSMUSG00000115067 AllianceGenome:MGI:2442042
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MBD-2; F630103D06Rik
    Summary
    Enables dipeptidase activity. Involved in leukotriene metabolic process. Located in membrane. Orthologous to human DPEP2 (dipeptidase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in lung adult (RPKM 5.2), mammary gland adult (RPKM 2.9) and 13 other tissues See more
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    Genomic context

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    See Dpep2 in Genome Data Viewer
    Location:
    8 D3; 8 53.07 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106711577..106732658, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105984945..106006026, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 12, member 4 Neighboring gene microRNA 7074 Neighboring gene STARR-seq mESC enhancer starr_22546 Neighboring gene predicted gene 45752 Neighboring gene dipeptidase 3 Neighboring gene predicted gene, 22972 Neighboring gene DEAD box helicase 28 Neighboring gene dihydrouridine synthase 2 Neighboring gene STARR-positive B cell enhancer ABC_E1375 Neighboring gene STARR-positive B cell enhancer ABC_E3801 Neighboring gene nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:108636517-108636718 Neighboring gene epithelial splicing regulatory protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Dpep2 Emerging as a Modulator of Macrophage Inflammation Confers Protection Against CVB3-Induced Viral Myocarditis. Yang X, et al. Front Cell Infect Microbiol, 2019. PMID 30899700, Free PMC Article
    2. Identification of two additional members of the membrane-bound dipeptidase family. Habib GM, et al. FASEB J, 2003 Jul. PMID 12738806
    3. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Taken together, this study revealed that Dpep2 could protect against Coxsackievirus B3-induced viral myocarditis by acting as a suppressor of macrophage inflammation.
      Title: Dpep2 Emerging as a Modulator of Macrophage Inflammation Confers Protection Against CVB3-Induced Viral Myocarditis.
    2. cloning and characterization of membrane-bound dipeptidase-2 and membrane-bound dipeptidase-3
      Title: Identification of two additional members of the membrane-bound dipeptidase family.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dipeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dipeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables exopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallodipeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in leukotriene D4 catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukotriene D4 catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in leukotriene metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dipeptidase 2
    Names
    membrane-bound dipeptidase 2
    putative membrane-bound dipeptidase 2
    NP_001288133.1
    NP_001288134.1
    NP_795887.2
    XP_006531144.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301204.1 → NP_001288133.1  dipeptidase 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001288133.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the most abundant transcript and encodes isoform 1.
      Source sequence(s)
      AK171503, BX634751, BY209853
      Consensus CDS
      CCDS80926.1
      UniProtKB/Swiss-Prot
      Q3TAV9, Q3TBF7, Q3TBK3, Q3TBM9, Q7TQ53, Q8C255
      UniProtKB/TrEMBL
      A0A2K6EDK8
      Related
      ENSMUSP00000034373.8, ENSMUST00000034373.8
      Conserved Domains (1) summary
      pfam01244
      Location:80 → 401
      Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

    2. NM_001301205.1 → NP_001288134.1  dipeptidase 2 isoform 2

      See identical proteins and their annotated locations for NP_001288134.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AK171503, BX634751, BY209853
      Consensus CDS
      CCDS80925.1
      UniProtKB/Swiss-Prot
      Q8C255
      Related
      ENSMUSP00000113877.2, ENSMUST00000117555.8
      Conserved Domains (1) summary
      pfam01244
      Location:1 → 308
      Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

    3. NM_176913.4 → NP_795887.2  dipeptidase 2 isoform 3

      See identical proteins and their annotated locations for NP_795887.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence, contains three alternate splice junctions, and contains an alternate 3' coding exon compared to variant 1. The resulting isoform (3) is longer at the N-terminus and has internal differences compared to isoform 1. This variant appears to be found rarely in nature.
      Source sequence(s)
      AF488552, AK171503, BX634751
      Consensus CDS
      CCDS22625.1
      UniProtKB/TrEMBL
      A0A2K6EDK8
      Related
      ENSMUSP00000080659.7, ENSMUST00000081998.13
      Conserved Domains (1) summary
      pfam01244
      Location:166 → 501
      Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      106711577..106732658 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531081.4 → XP_006531144.1  dipeptidase 2 isoform X1

      UniProtKB/TrEMBL
      A0A2K6EDK8
      Conserved Domains (1) summary
      pfam01244
      Location:213 → 534
      Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C255.1 GenPept UniProtKB/Swiss-Prot:Q8C255

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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