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    Tmem198 transmembrane protein 198 [ Mus musculus (house mouse) ]

    Gene ID: 319998, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tmem198provided by MGI
    Official Full Name
    transmembrane protein 198provided by MGI
    Primary source
    MGI:MGI:2443133
    See related
    Ensembl:ENSMUSG00000051703 AllianceGenome:MGI:2443133
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmem198a; Tmem198-1; A230078I05Rik
    Summary
    Predicted to be involved in positive regulation of canonical Wnt signaling pathway. Predicted to be active in cytoplasmic vesicle and plasma membrane. Is expressed in brain and ventral grey horn. Orthologous to human TMEM198 (transmembrane protein 198). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cortex adult (RPKM 21.3), frontal lobe adult (RPKM 17.1) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem198 in Genome Data Viewer
    Location:
    1 C4; 1 39.15 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (75456115..75462337)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (75479532..75485693)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene GDP-mannose pyrophosphorylase A Neighboring gene STARR-seq mESC enhancer starr_01359 Neighboring gene predicted gene, 53564 Neighboring gene acid-sensing ion channel family member 4 Neighboring gene predicted gene, 32506 Neighboring gene STARR-positive B cell enhancer ABC_E1997 Neighboring gene chondroitin polymerizing factor Neighboring gene obscurin-like 1 Neighboring gene STARR-seq mESC enhancer starr_01360 Neighboring gene inhibin alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 198

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433351.1 → NP_001420280.1  transmembrane protein 198 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC115011

    2. NM_001433352.1 → NP_001420281.1  transmembrane protein 198 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC115011

    3. NM_001433356.1 → NP_001420285.1  transmembrane protein 198 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC115011

    4. NM_177056.5 → NP_796030.1  transmembrane protein 198 isoform 2

      See identical proteins and their annotated locations for NP_796030.1

      Status: VALIDATED

      Source sequence(s)
      AC115011
      Consensus CDS
      CCDS15076.1
      UniProtKB/Swiss-Prot
      Q8BG75
      Related
      ENSMUSP00000109205.3, ENSMUST00000113575.9
      Conserved Domains (1) summary
      pfam13886
      Location:47 → 236
      DUF4203; Domain of unknown function (DUF4203)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      75456115..75462337
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165696.1 → XP_036021589.1  transmembrane protein 198 isoform X1

      Conserved Domains (1) summary
      pfam13886
      Location:120 → 316
      DUF4203; Domain of unknown function (DUF4203)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BG75.1 GenPept UniProtKB/Swiss-Prot:Q8BG75

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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