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    Nceh1 neutral cholesterol ester hydrolase 1 [ Mus musculus (house mouse) ]

    Gene ID: 320024, updated on 27-Nov-2024

    Summary

    Official Symbol
    Nceh1provided by MGI
    Official Full Name
    neutral cholesterol ester hydrolase 1provided by MGI
    Primary source
    MGI:MGI:2443191
    See related
    Ensembl:ENSMUSG00000027698 AllianceGenome:MGI:2443191
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nceh; CPO-BP; Aadacl1; B230106I24Rik
    Summary
    Enables phosphate ion binding activity and serine hydrolase activity. Involved in ether lipid metabolic process. Acts upstream of or within protein dephosphorylation and xenobiotic metabolic process. Located in membrane. Is expressed in nervous system; retina; and tooth. Orthologous to human NCEH1 (neutral cholesterol ester hydrolase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in kidney adult (RPKM 41.2), adrenal adult (RPKM 26.8) and 17 other tissues See more
    Orthologs
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    Genomic context

    See Nceh1 in Genome Data Viewer
    Location:
    3 A3; 3 10.82 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (27237153..27299112)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (27183004..27245266)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ect2 oncogene Neighboring gene predicted gene, 25152 Neighboring gene RIKEN cDNA 1700125G22 gene Neighboring gene STARR-seq mESC enhancer starr_07226 Neighboring gene STARR-seq mESC enhancer starr_07227 Neighboring gene STARR-seq mESC enhancer starr_07228 Neighboring gene STARR-seq mESC enhancer starr_07232 Neighboring gene STARR-positive B cell enhancer ABC_E6045 Neighboring gene predicted gene, 42192 Neighboring gene STARR-seq mESC enhancer starr_07234 Neighboring gene glycine cleavage system protein H (aminomethyl carrier) pseudogene Neighboring gene tumor necrosis factor (ligand) superfamily, member 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetylalkylglycerol acetylhydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphate ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables serine hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    neutral cholesterol ester hydrolase 1
    Names
    2-acetyl MAGE hydrolase
    acetylalkylglycerol acetylhydrolase
    arylacetamide deacetylase-like 1
    chlorpyrifos oxon-binding protein
    NP_848887.1
    XP_011247986.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178772.4NP_848887.1  neutral cholesterol ester hydrolase 1

      See identical proteins and their annotated locations for NP_848887.1

      Status: VALIDATED

      Source sequence(s)
      AC121099, AC157919
      Consensus CDS
      CCDS17271.1
      UniProtKB/Swiss-Prot
      Q69ZL0, Q8BLF1, Q8BZK3
      Related
      ENSMUSP00000045864.9, ENSMUST00000046515.15
      Conserved Domains (2) summary
      COG0657
      Location:73385
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam07859
      Location:109382
      Abhydrolase_3; alpha/beta hydrolase fold

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      27237153..27299112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249684.2XP_011247986.1  neutral cholesterol ester hydrolase 1 isoform X1

      Conserved Domains (1) summary
      cl21494
      Location:1248
      Abhydrolase; alpha/beta hydrolases