Snrnp200 small nuclear ribonucleoprotein 200 (U5) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Snrnp200provided by MGI
Official Full Name: small nuclear ribonucleoprotein 200 (U5)provided by MGI
Primary source: MGI:MGI:2444401
See related: Ensembl:ENSMUSG00000003660 AllianceGenome:MGI:2444401
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HELIC2; Ascc3l1; U5-200KD; U5-200-KD; A330064G03Rik
Summary: On February 19, 2002, this locus was switched from human to mouse. The source accession, Z70200.1, is almost identical to the mouse BAC clone AC074224, and it matches the mouse cDNA accession BC011390 as well. The human gene is LocusID 23020. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in thymus adult (RPKM 28.4), CNS E11.5 (RPKM 26.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 F1; 2 61.84 cM

Exon count:: 45

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (127050306..127082373)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (127208386..127240453)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)
Transgenic (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ascc3l1 (e-PCR), detects polymorphism
- UniSTS:479072

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

27.MMHAP25FLA6.seq (e-PCR)
- UniSTS:123778

GDB:182527 (e-PCR)
- UniSTS:155386

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA helicase activity	ISO Inferred from Sequence Orthology more info
enables RNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)	IBA Inferred from Biological aspect of Ancestor more info
involved_in spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)	IEA Inferred from Electronic Annotation more info
involved_in spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of U2-type catalytic step 1 spliceosome	ISO Inferred from Sequence Orthology more info
part_of U2-type catalytic step 1 spliceosome	ISS Inferred from Sequence or Structural Similarity more info
part_of U2-type precatalytic spliceosome	ISO Inferred from Sequence Orthology more info
part_of U2-type precatalytic spliceosome	ISS Inferred from Sequence or Structural Similarity more info
part_of U4/U6 x U5 tri-snRNP complex	IEA Inferred from Electronic Annotation more info
part_of U4/U6 x U5 tri-snRNP complex	ISO Inferred from Sequence Orthology more info
part_of U5 snRNP	IEA Inferred from Electronic Annotation more info
part_of U5 snRNP	ISO Inferred from Sequence Orthology more info
part_of catalytic step 2 spliceosome	IEA Inferred from Electronic Annotation more info
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info
part_of spliceosomal complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: U5 small nuclear ribonucleoprotein 200 kDa helicase

Names: BRR2 homolog; U5 snRNP-specific protein, 200 kDa (DEXH RNA helicase family); activating signal cointegrator 1 complex subunit 3-like 1

NP_796188.2

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177214.5 → NP_796188.2 U5 small nuclear ribonucleoprotein 200 kDa helicase

See identical proteins and their annotated locations for NP_796188.2

Status: VALIDATED

Source sequence(s)

AL845368

Consensus CDS

CCDS16695.1

UniProtKB/Swiss-Prot

Q69ZZ3, Q6P4T2

Related

ENSMUSP00000099509.4, ENSMUST00000103220.4

Conserved Domains (7) summary

smart00490
Location:1616 → 1694

HELICc; helicase superfamily c-terminal domain

smart00487
Location:1320 → 1508

DEXDc; DEAD-like helicases superfamily

smart00611
Location:1809 → 2125

SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins

COG1204
Location:452 → 1241

BRR2; Replicative superfamily II helicase [Replication, recombination and repair]

cd00079
Location:684 → 870

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

pfam00270
Location:1329 → 1500

DEAD; DEAD/DEAH box helicase

pfam02889
Location:982 → 1285

Sec63; Sec63 Brl domain