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    CycD Cyclin D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32551, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CycDprovided by FlyBase
    Official Full Name
    Cyclin Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010315
    Locus tag
    Dmel_CG9096
    See related
    AllianceGenome:FB:FBgn0010315
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cdi3; Cdi3; CDI3; CG9096; Cyc D; Cyc-D; cycD; CYCD; cyclin D; cyclinD; dCycD; DmcycD; Dmel\CG9096
    Summary
    Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in positive regulation of cell growth; positive regulation of signal transduction; and regulation of mitochondrion organization. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Is expressed in embryonic/larval midgut; eye disc morphogenetic furrow; eye-antennal disc; imaginal disc; and organism. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); endocrine gland cancer (multiple); hematologic cancer (multiple); and hepatitis B. Orthologous to human CCND1 (cyclin D1); CCND2 (cyclin D2); and CCND3 (cyclin D3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See CycD in Genome Data Viewer
    Location:
    13F18-14A1; 1-52 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15906822..15909676, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15800855..15803709, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene shibire Neighboring gene LDL receptor related protein 4 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Live cell cycle analysis of Drosophila tissues using the Attune Acoustic Focusing Cytometer and Vybrant DyeCycle violet DNA stain. Flegel K, et al. J Vis Exp, 2013 May 19. PMID 23712023, Free PMC Article
    2. Conversion of quiescent niche cells to somatic stem cells causes ectopic niche formation in the Drosophila testis. Hétié P, et al. Cell Rep, 2014 May 8. PMID 24746819, Free PMC Article
    3. [Phase-specific elements of the regulatory zone of the Drosophila melanogaster string gene]. Trunova SA, et al. Genetika, 2001 Dec. PMID 11785287
    4. Drosophila cyclin D/Cdk4 requires Hif-1 prolyl hydroxylase to drive cell growth. Frei C, et al. Dev Cell, 2004 Feb. PMID 14960278
    5. Histone H2A T120 Phosphorylation Promotes Oncogenic Transformation via Upregulation of Cyclin D1. Aihara H, et al. Mol Cell, 2016 Oct 6. PMID 27716482

    See all (194) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Histone H2A T120 phosphorylation promotes oncogenic transformation via upregulation of cyclin D1.
      Title: Histone H2A T120 Phosphorylation Promotes Oncogenic Transformation via Upregulation of Cyclin D1.
    2. The results indicate that the precise regulation of neuronal CycD activity is important to limit mitochondrial reactive oxygen species production and prevent neurodegeneration.
      Title: Changes in neuronal CycD/Cdk4 activity affect aging, neurodegeneration, and oxidative stress.
    3. Loss of Cyclin D increase L-Lactate dehydrigenase protein in normoxia.
      Title: Drosophila cyclin D/Cdk4 regulates mitochondrial biogenesis and aging and sensitizes animals to hypoxic stress.
    4. Delg and cyclin D/Cdk4 have roles in nutritional control of mitochondrial biogenesis in the Drosophila adipose tissue
      Title: Nutrition controls mitochondrial biogenesis in the Drosophila adipose tissue through Delg and cyclin D/Cdk4.
    5. Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E.
      Title: Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E.
    6. mRpL12 is required for CycD/Cdk4-induced cell growth
      Title: The Drosophila mitochondrial ribosomal protein mRpL12 is required for Cyclin D/Cdk4-driven growth.
    7. Cyclin D-cdk4 is not a master regulator of cell multiplication in Drosophila embryos
      Title: Cyclin D-cdk4 is not a master regulator of cell multiplication in Drosophila embryos.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of mitochondrion organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin D
    Names
    CG9096-PD
    CG9096-PE
    CG9096-PF
    CycD-PD
    CycD-PE
    CycD-PF
    Cyclin-dependent kinase interactor 3
    cyclinD
    dCyclinD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15906822..15909676 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078631.4 → NP_523355.2  cyclin D, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523355.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KUZ5, Q9VXM1
      Conserved Domains (2) summary
      pfam00134
      Location:155 → 280
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:282 → 392
      Cyclin_C; Cyclin, C-terminal domain

    2. NM_167472.3 → NP_727912.2  cyclin D, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727912.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KUZ5, Q9VXM1
      Conserved Domains (2) summary
      pfam00134
      Location:155 → 280
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:282 → 392
      Cyclin_C; Cyclin, C-terminal domain

    3. NM_167473.2 → NP_727913.2  cyclin D, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727913.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KUZ5, Q9VXM1
      Conserved Domains (2) summary
      pfam00134
      Location:155 → 280
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:282 → 392
      Cyclin_C; Cyclin, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24158 Q24158
    Q7KUZ5 Q7KUZ5
    Q9GTQ8 Q9GTQ8
    Q9VXM1 Q9VXM1

    Gene LinkOut

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