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    Spn28Db Serpin 28Db [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 326261, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spn28Dbprovided by FlyBase
    Official Full Name
    Serpin 28Dbprovided by FlyBase
    Primary source
    FLYBASE:FBgn0053121
    Locus tag
    Dmel_CG33121
    See related
    AllianceGenome:FB:FBgn0053121
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12318; CG33121; Dmel\CG33121
    Summary
    Involved in sexual reproduction. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in intermediate coronary syndrome; neurodegenerative disease (multiple); thrombophilia (multiple); thrombosis; and toxic shock syndrome. Orthologous to several human genes including SERPINA12 (serpin family A member 12); SERPINB1 (serpin family B member 1); and SERPINC1 (serpin family C member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Spn28Db in Genome Data Viewer
    Location:
    28D2-28D2; 2-29 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7889288..7890704, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7889288..7890594, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Serpin 28Da Neighboring gene Sno oncogene Neighboring gene uncharacterized protein Neighboring gene peste

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Intermolecular Interactions Drive Protein Adaptive and Coadaptive Evolution at Both Species and Population Levels. Peng J, et al. Mol Biol Evol, 2022 Jan 7. PMID 34878126, Free PMC Article
    2. Quantitative Proteomics Identification of Seminal Fluid Proteins in Male Drosophila melanogaster. Sepil I, et al. Mol Cell Proteomics, 2019 Mar 15. PMID 30287546, Free PMC Article
    3. The Drosophila serpins: multiple functions in immunity and morphogenesis. Reichhart JM, et al. Methods Enzymol, 2011. PMID 21683256
    4. Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomes. Garrett M, et al. BMC Genomics, 2009 Oct 22. PMID 19849829, Free PMC Article
    5. FlyXCDB-A Resource for Drosophila Cell Surface and Secreted Proteins and Their Extracellular Domains. Pei J, et al. J Mol Biol, 2018 Sep 14. PMID 29890119

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase inhibitor activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    NOT enables serine-type endopeptidase inhibitor activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in sexual reproduction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serpin 28Db
    Names
    CG33121-PB
    Spn28Db-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7889288..7890704 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001370007.1 → NP_001356884.1  serpin 28Db [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VLV3
      Conserved Domains (1) summary
      cd00172
      Location:22 → 368
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VLV3 Q9VLV3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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