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    goe gone early [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32660, updated on 9-Dec-2024

    Summary

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    Official Symbol
    goeprovided by FlyBase
    Official Full Name
    gone earlyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027528
    Locus tag
    Dmel_CG9634
    See related
    AllianceGenome:FB:FBgn0027528
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD21405; CG9634; Dmel\CG9634; Nepl2
    Summary
    Involved in negative regulation of stem cell differentiation and oogenesis. Located in plasma membrane. Is expressed in several structures, including adult head; mesectoderm; mesectoderm anlage; midline primordium; and unpaired neurons. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See goe in Genome Data Viewer
    Location:
    15A3-15A5; 1-55 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16727304..16751910, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16621337..16645943, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene TweedleX Neighboring gene TweedleY Neighboring gene TweedleZ Neighboring gene Tweedlealpha Neighboring gene uncharacterized protein Neighboring gene inflated Neighboring gene mitochondrial ribosomal protein L22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. gone early, a novel germline factor, ensures the proper size of the stem cell precursor pool in the Drosophila ovary. Matsuoka S, et al. PLoS One, 2014. PMID 25420147, Free PMC Article
    2. Exploring the Caenorhabditis elegans and Drosophila melanogaster genomes to understand neuropeptide and peptidase function. Coates D, et al. Biochem Soc Trans, 2000. PMID 10961941
    3. Neprilysins: an evolutionarily conserved family of metalloproteases that play important roles in reproduction in Drosophila. Sitnik JL, et al. Genetics, 2014 Mar. PMID 24395329, Free PMC Article
    4. Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. Meyer H, et al. MicroPubl Biol, 2021 Jun 23. PMID 34189422, Free PMC Article
    5. Probing the canonicity of the Wnt/Wingless signaling pathway. Franz A, et al. PLoS Genet, 2017 Apr. PMID 28369070, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that a germline factor, Gone early (Goe, CG9634) limits the fraction of primordial germ cells (PGCs) that initiate gametogenesis.
      Title: gone early, a novel germline factor, ensures the proper size of the stem cell precursor pool in the Drosophila ovary.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gone early
    Names
    CG9634-PA
    CG9634-PB
    CG9634-PC
    Neprilysin-like 2
    goe-PA
    goe-PB
    goe-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16727304..16751910 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298420.1 → NP_001285349.1  gone early, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285349.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JFT2
      Conserved Domains (1) summary
      cl14813
      Location:179 → 689
      GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

    2. NM_132932.3 → NP_573160.1  gone early, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573160.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XZ14
      Related
      FBpp0074133
      Conserved Domains (1) summary
      cl14813
      Location:184 → 694
      GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

    3. NM_001298421.1 → NP_001285350.1  gone early, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285350.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XZ14
      Conserved Domains (1) summary
      cl14813
      Location:184 → 694
      GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XZ14.1 Q9XZ14
    X2JFT2 X2JFT2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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