baz bazooka [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: bazprovided by FlyBase
Official Full Name: bazookaprovided by FlyBase
Primary source: FLYBASE:FBgn0000163
Locus tag: Dmel_CG5055
See related: AllianceGenome:FB:FBgn0000163
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Baz; BAZ; Baz/Par-3; Baz/Par3; Bazooka; CG5055; D-par3; D-Par3; Dmel\CG5055; dPar-3; l(1)G0484; par-3; Par-3; PAR-3; par3; Par3; PAR3
Summary: Enables phosphatidic acid binding activity and phosphatidylinositol binding activity. Involved in several processes, including cell junction assembly; generation of neurons; and oogenesis. Located in cytoplasmic side of apical plasma membrane; spot adherens junction; and zonula adherens. Part of PAR polarity complex. Is expressed in several structures, including Malpighian tubule Type II cell; NMJ bouton; chordotonal neurons; germline cell; and somatic cell of ovariole. Used to study developmental disorder of mental health. Orthologous to several human genes including PARD3 (par-3 family cell polarity regulator). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 15F1-15F2; 1-57 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (17160006..17200728)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (17054039..17094738)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel protein Moat prevents ectopic epithelial folding by limiting Bazooka/Par3-dependent adherens junctions.
Title: A novel protein Moat prevents ectopic epithelial folding by limiting Bazooka/Par3-dependent adherens junctions.
Par3/bazooka binds NICD and promotes notch signaling during Drosophila development.
Title: Par3/bazooka binds NICD and promotes notch signaling during Drosophila development.
A CDK1 phosphorylation site on Drosophila PAR-3 regulates neuroblast polarisation and sensory organ formation.
Title: A CDK1 phosphorylation site on Drosophila PAR-3 regulates neuroblast polarisation and sensory organ formation.
Re-assessment of the subcellular localization of Bazooka/Par-3 in Drosophila: no evidence for localization to the nucleus and the neuromuscular junction.
Title: Re-assessment of the subcellular localization of Bazooka/Par-3 in Drosophila: no evidence for localization to the nucleus and the neuromuscular junction.
Par-3 family proteins in cell polarity & adhesion.
Title: Par-3 family proteins in cell polarity & adhesion.
Par3 cooperates with Sanpodo for the assembly of Notch clusters following asymmetric division of Drosophila sensory organ precursor cells.
Title: Par3 cooperates with Sanpodo for the assembly of Notch clusters following asymmetric division of Drosophila sensory organ precursor cells.
A Conserved PDZ-Binding Motif in aPKC Interacts with Par-3 and Mediates Cortical Polarity.
Title: A Conserved PDZ-Binding Motif in aPKC Interacts with Par-3 and Mediates Cortical Polarity.
These results point to a connection between membrane trafficking and dynein-mediated transport to sustain PAR3 asymmetry.
Title: Dynein-mediated transport and membrane trafficking control PAR3 polarised distribution.
The results indicated that elevated Par3 expression induces cortical localization of the Par-complex at the interphase.
Title: Reconstruction of Par-dependent polarity in apolar cells reveals a dynamic process of cortical polarization.
The authors show that during Drosophila dorsal closure fusing cell interfaces are remodelled from en-face contacts at fusion to an interlocking arrangement after fusion, and demonstrate that changes in interface length and geometry are dependent on the spatiotemporal regulation of cytoskeletal tension and Bazooka/Par3.
Title: Cytoskeletal tension and Bazooka tune interface geometry to ensure fusion fidelity and sheet integrity during dorsal closure.

Submit: New GeneRIF Correction See all GeneRIFs (46)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 17167449-17167542 mobile_element_type = transposon:INE-1{}4211

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables phosphatidic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Malpighian tubule development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adherens junction organization	HGI more info	PubMed
involved_in apical protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in asymmetric neuroblast division	IGI Inferred from Genetic Interaction more info	PubMed
involved_in asymmetric neuroblast division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in asymmetric protein localization involved in cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axis elongation	IDA Inferred from Direct Assay more info	PubMed
involved_in border follicle cell delamination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branching involved in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of apical/basal cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of centrosome localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-band extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived oocyte fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte anterior/posterior axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of establishment of planar polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of establishment of planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in zonula adherens assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of PAR polarity complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in apical junction complex	IBA Inferred from Biological aspect of Ancestor more info
located_in apical junction complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic side of apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in spot adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in zonula adherens	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: bazooka

Names: Baz; Bazooka-Par3; Bazooka/Par-3; Bazooka/Par3; CG5055-PA; CG5055-PB; CG5055-PC; CG5055-PD; baz-PA; baz-PB; baz-PC; baz-PD; par-3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

17160006..17200728

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001347807.1 → NP_001334669.1 bazooka, isoform A [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

O96782, Q9VX75
NM_001042818.4 → NP_001036283.1 bazooka, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036283.1

Status: REVIEWED

UniProtKB/TrEMBL

O96782, Q0KHR3

Conserved Domains (3) summary

cd00992
Location:462 → 548

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:62 → 174

DUF3534; Domain of unknown function (DUF3534)

cl00663
Location:390 → 436

CRS1_YhbY; CRS1 / YhbY (CRM) domain
NM_001298436.2 → NP_001285365.1 bazooka, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285365.1

Status: REVIEWED

UniProtKB/TrEMBL

O96782, X2JCB3

Conserved Domains (3) summary

cd00992
Location:462 → 548

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:62 → 174

DUF3534; Domain of unknown function (DUF3534)

cl00663
Location:390 → 436

CRS1_YhbY; CRS1 / YhbY (CRM) domain
NM_001298435.2 → NP_001285364.1 bazooka, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285364.1

Status: REVIEWED

UniProtKB/TrEMBL

O96782, X2JFU8

Conserved Domains (3) summary

cd00992
Location:441 → 527

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12053
Location:1 → 153

DUF3534; Domain of unknown function (DUF3534)

cl00663
Location:369 → 415

CRS1_YhbY; CRS1 / YhbY (CRM) domain