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    Fbxo41 F-box protein 41 [ Mus musculus (house mouse) ]

    Gene ID: 330369, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fbxo41provided by MGI
    Official Full Name
    F-box protein 41provided by MGI
    Primary source
    MGI:MGI:1261912
    See related
    Ensembl:ENSMUSG00000047013 AllianceGenome:MGI:1261912
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9630017H13; D6Ertd538e
    Summary
    Is expressed in several structures, including forelimb bud; male reproductive gland or organ; nervous system; notochord; and sensory organ. Orthologous to human FBXO41 (F-box protein 41). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 14.6), frontal lobe adult (RPKM 13.2) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fbxo41 in Genome Data Viewer
    Location:
    6 C3; 6 37.48 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (85446556..85479976, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (85469574..85502994, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene SET and MYND domain containing 5 Neighboring gene protease-associated domain containing 1 Neighboring gene chaperonin containing TCP1 subunit 7 Neighboring gene early growth response 4 Neighboring gene ALMS1, centrosome and basal body associated Neighboring gene STARR-seq mESC enhancer starr_16505 Neighboring gene N-acetyltransferase 8 (GCN5-related) family member 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Neuronal F-Box protein FBXO41 regulates synaptic transmission and hippocampal network maturation. Quadros ARAA, et al. iScience, 2022 Apr 15. PMID 35372812, Free PMC Article
    2. Fbxo41 Promotes Disassembly of Neuronal Primary Cilia. King CR, et al. Sci Rep, 2019 Jun 3. PMID 31160656, Free PMC Article
    3. Loss of the neuron-specific F-box protein FBXO41 models an ataxia-like phenotype in mice with neuronal migration defects and degeneration in the cerebellum. Mukherjee C, et al. J Neurosci, 2015 Jun 10. PMID 26063905, Free PMC Article
    4. Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry. Del Mar Masdeu M, et al. Oncotarget, 2017 Nov 24. PMID 29254152, Free PMC Article
    5. Global gene expression analysis of murine limb development. Taher L, et al. PLoS One, 2011. PMID 22174793, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fbxo41 Promotes Disassembly of Neuronal Primary Cilia.
      Title: Fbxo41 Promotes Disassembly of Neuronal Primary Cilia.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within dentate gyrus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hippocampus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    F-box only protein 41

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001160.3 → NP_001001160.1  F-box only protein 41

      See identical proteins and their annotated locations for NP_001001160.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK147230, BC070445, CD774837
      Consensus CDS
      CCDS20296.1
      UniProtKB/Swiss-Prot
      Q6NS60, Q6P7W4, Q6ZPG1
      UniProtKB/TrEMBL
      Q3UGY7
      Related
      ENSMUSP00000124524.2, ENSMUST00000161078.8
      Conserved Domains (5) summary
      TIGR02473
      Location:216 → 348
      flagell_FliJ; flagellar export protein FliJ
      sd00017
      Location:10 → 33
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00034
      Location:657 → 683
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:555 → 593
      F-box-like; F-box-like
      pfam16515
      Location:237 → 299
      HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

    2. NM_001289674.1 → NP_001276603.1  F-box only protein 41

      See identical proteins and their annotated locations for NP_001276603.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site and lacks an exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK147230, BC070445, CD774837
      Consensus CDS
      CCDS20296.1
      UniProtKB/Swiss-Prot
      Q6NS60, Q6P7W4, Q6ZPG1
      UniProtKB/TrEMBL
      Q3UGY7
      Related
      ENSMUSP00000125671.2, ENSMUST00000159062.8
      Conserved Domains (5) summary
      TIGR02473
      Location:216 → 348
      flagell_FliJ; flagellar export protein FliJ
      sd00017
      Location:10 → 33
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00034
      Location:657 → 683
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:555 → 593
      F-box-like; F-box-like
      pfam16515
      Location:237 → 299
      HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

    3. NM_001289675.1 → NP_001276604.1  F-box only protein 41

      See identical proteins and their annotated locations for NP_001276604.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK147230, AK147681, BC070445, CD774837
      Consensus CDS
      CCDS20296.1
      UniProtKB/Swiss-Prot
      Q6NS60, Q6P7W4, Q6ZPG1
      UniProtKB/TrEMBL
      Q3UGY7
      Related
      ENSMUSP00000124754.2, ENSMUST00000161546.2
      Conserved Domains (5) summary
      TIGR02473
      Location:216 → 348
      flagell_FliJ; flagellar export protein FliJ
      sd00017
      Location:10 → 33
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00034
      Location:657 → 683
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:555 → 593
      F-box-like; F-box-like
      pfam16515
      Location:237 → 299
      HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      85446556..85479976 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NS60.3 GenPept UniProtKB/Swiss-Prot:Q6NS60

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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