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    ATP6V1B1 ATPase H+ transporting V1 subunit B1 [ Bos taurus (domestic cattle) ]

    Gene ID: 338059, updated on 29-Jan-2025

    Summary

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    Official Symbol
    ATP6V1B1provided by VGNC
    Official Full Name
    ATPase H+ transporting V1 subunit B1provided by VGNC
    Primary source
    VGNC:VGNC:26317
    See related
    Ensembl:ENSBTAG00000010620
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ATP6V1B1 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (13454334..13480401, complement)

    Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene N-acetylglucosamine kinase Neighboring gene testis expressed 261 Neighboring gene ankyrin repeat domain 53 Neighboring gene uncharacterized LOC112448754 Neighboring gene ventral anterior homeobox 2 Neighboring gene CD207 molecule

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Molecular identification, immunolocalization, and functional activity of a vacuolar-type H(+)-ATPase in bovine rumen epithelium. Albrecht E, et al. J Comp Physiol B, 2008 Mar. PMID 17989983
    2. Selectively amplified expression of an isoform of the vacuolar H(+)-ATPase 56-kilodalton subunit in renal intercalated cells. Nelson RD, et al. Proc Natl Acad Sci U S A, 1992 Apr 15. PMID 1373501, Free PMC Article
    3. Molecular cloning and characterization of Atp6v1b1, the murine vacuolar H+ -ATPase B1-subunit. Finberg KE, et al. Gene, 2003 Oct 30. PMID 14585495
    4. Cryo-EM structures of intact V-ATPase from bovine brain. Wang R, et al. Nat Commun, 2020 Aug 6. PMID 32764564, Free PMC Article
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. vH(+)-ATPase has been detected in the cell membrane and in intracellular pools in bovine rumen epithelium.
      Title: Molecular identification, immunolocalization, and functional activity of a vacuolar-type H(+)-ATPase in bovine rumen epithelium.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in vacuolar acidification IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of proton-transporting V-type ATPase, V1 domain IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    V-type proton ATPase subunit B, kidney isoform
    Names
    ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 (Renal tubular acidosis with deafness)
    V-ATPase subunit B 1
    endomembrane proton pump 58 kDa subunit
    vacuolar H+-ATPase
    vacuolar proton pump subunit B 1
    NP_788827.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176654.2 → NP_788827.1  V-type proton ATPase subunit B, kidney isoform

      See identical proteins and their annotated locations for NP_788827.1

      Status: PROVISIONAL

      Source sequence(s)
      M88691
      UniProtKB/Swiss-Prot
      P31407
      UniProtKB/TrEMBL
      A0AAA9RWP7
      Related
      ENSBTAP00070012411.1, ENSBTAT00070021121.1
      Conserved Domains (4) summary
      cd01135
      Location:112 → 395
      V_A-ATPase_B; V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi ...
      TIGR01040
      Location:40 → 504
      V-ATPase_V1_B; V-type (H+)-ATPase V1, B subunit
      pfam00306
      Location:410 → 497
      ATP-synt_ab_C; ATP synthase alpha/beta chain, C terminal domain
      pfam02874
      Location:44 → 110
      ATP-synt_ab_N; ATP synthase alpha/beta family, beta-barrel domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      13454334..13480401 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P31407.1 GenPept UniProtKB/Swiss-Prot:P31407

    Gene LinkOut

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