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    Tmem241 transmembrane protein 241 [ Mus musculus (house mouse) ]

    Gene ID: 338363, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tmem241provided by MGI
    Official Full Name
    transmembrane protein 241provided by MGI
    Primary source
    MGI:MGI:2442435
    See related
    Ensembl:ENSMUSG00000049411 AllianceGenome:MGI:2442435
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6030446N20Rik
    Summary
    Predicted to enable UDP-N-acetylglucosamine transmembrane transporter activity and antiporter activity. Predicted to be involved in UDP-N-acetylglucosamine transmembrane transport. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Orthologous to human TMEM241 (transmembrane protein 241). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Tmem241 in Genome Data Viewer
    Location:
    18 A1; 18 5.98 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (12113193..12254604, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (11980119..12121570, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43817 Neighboring gene CDK5 and Abl enzyme substrate 1 Neighboring gene microRNA 1901 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:12094438-12094547 Neighboring gene predicted gene, 41666 Neighboring gene STARR-seq mESC enhancer starr_43825 Neighboring gene STARR-seq mESC enhancer starr_43827 Neighboring gene STARR-seq mESC enhancer starr_43828 Neighboring gene STARR-seq mESC enhancer starr_43830 Neighboring gene STARR-positive B cell enhancer ABC_E4239 Neighboring gene predicted gene, 41667 Neighboring gene RIO kinase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TMEM241 is a UDP-N-acetylglucosamine transporter required for M6P modification of NPC2 and cholesterol transport. Zhao N, et al. J Lipid Res, 2023 Dec. PMID 37890669, Free PMC Article
    2. Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription. Liu N, et al. Nat Commun, 2022 Aug 11. PMID 35953472, Free PMC Article
    3. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TMEM241 is a UDP-N-acetylglucosamine transporter required for M6P modification of NPC2 and cholesterol transport.
      Title: TMEM241 is a UDP-N-acetylglucosamine transporter required for M6P modification of NPC2 and cholesterol transport.
    2. Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription.
      Title: Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2)  1 citation
    • Gene trapped (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP-mannose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-N-acetylglucosamine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables UDP-N-acetylglucosamine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in GDP-mannose transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in UDP-N-acetylglucosamine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in UDP-N-acetylglucosamine transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    UDP-N-acetylglucosamine transporter TMEM241; transmembrane protein 241
    Names
    transmembrane protein C18orf45 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289666.1 → NP_001276595.1  UDP-N-acetylglucosamine transporter TMEM241 isoform 1

      See identical proteins and their annotated locations for NP_001276595.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK038472, AK051727
      Consensus CDS
      CCDS84358.1
      UniProtKB/Swiss-Prot
      Q3UME2, Q8BQ16, Q8CAM4, Q8CAM9, Q8CD42
      UniProtKB/TrEMBL
      B2RPV5
      Related
      ENSMUSP00000147687.2, ENSMUST00000209859.2
      Conserved Domains (1) summary
      COG5070
      Location:10 → 193
      VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

    2. NM_001289667.1 → NP_001276596.1  UDP-N-acetylglucosamine transporter TMEM241 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This results in a shorter isoform (3) that has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK038472, AK051727, BC094382
      UniProtKB/TrEMBL
      A0A1B0GSM8

    3. NM_178801.5 → NP_848916.2  UDP-N-acetylglucosamine transporter TMEM241 isoform 2

      See identical proteins and their annotated locations for NP_848916.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. This results in a shorter isoform (2) that has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK038472, AK051727, BC094382
      Consensus CDS
      CCDS84359.1
      UniProtKB/TrEMBL
      B2RPV5
      Related
      ENSMUSP00000052001.8, ENSMUST00000055447.14
      Conserved Domains (1) summary
      COG5070
      Location:10 → 193
      VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

    RNA

    1. NR_110356.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK031517, AK038472, AK051727
      Related
      ENSMUST00000211298.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      12113193..12254604 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526053.5 → XP_006526116.1  transmembrane protein 241 isoform X5

      UniProtKB/TrEMBL
      B2RPV5
      Conserved Domains (1) summary
      COG5070
      Location:122 → 243
      VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

    2. XM_006526056.5 → XP_006526119.1  transmembrane protein 241 isoform X8

      UniProtKB/TrEMBL
      B2RPV5
      Conserved Domains (1) summary
      COG5070
      Location:122 → 243
      VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

    3. XM_011246964.4 → XP_011245266.1  transmembrane protein 241 isoform X7

      See identical proteins and their annotated locations for XP_011245266.1

      Conserved Domains (1) summary
      COG5070
      Location:104 → 243
      VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

    4. XM_006526055.5 → XP_006526118.1  transmembrane protein 241 isoform X7

      See identical proteins and their annotated locations for XP_006526118.1

      Conserved Domains (1) summary
      COG5070
      Location:104 → 243
      VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

    5. XM_030250518.2 → XP_030106378.1  transmembrane protein 241 isoform X17

      UniProtKB/TrEMBL
      B2RPV5
      Conserved Domains (1) summary
      COG5070
      Location:10 → 167
      VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

    6. XM_036161196.1 → XP_036017089.1  transmembrane protein 241 isoform X25

      Conserved Domains (1) summary
      COG5070
      Location:10 → 100
      VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

    7. XM_036161192.1 → XP_036017085.1  transmembrane protein 241 isoform X16

      UniProtKB/TrEMBL
      B2RPV5

    8. XM_036161193.1 → XP_036017086.1  transmembrane protein 241 isoform X19

      UniProtKB/TrEMBL
      B2RPV5

    9. XM_030250519.2 → XP_030106379.1  transmembrane protein 241 isoform X22

      Conserved Domains (1) summary
      COG5070
      Location:10 → 193
      VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

    10. XM_036161191.1 → XP_036017084.1  transmembrane protein 241 isoform X13

      UniProtKB/TrEMBL
      B2RPV5

    11. XM_011246967.4 → XP_011245269.1  transmembrane protein 241 isoform X18

      Conserved Domains (1) summary
      COG5070
      Location:104 → 243
      VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

    12. XM_036161194.1 → XP_036017087.1  transmembrane protein 241 isoform X21

      UniProtKB/TrEMBL
      B2RPV5
      Conserved Domains (1) summary
      COG5070
      Location:21 → 142
      VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

    13. XM_006526057.5 → XP_006526120.1  transmembrane protein 241 isoform X9

      Conserved Domains (1) summary
      COG5070
      Location:104 → 243
      VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

    14. XM_006526059.5 → XP_006526122.1  transmembrane protein 241 isoform X11

      Conserved Domains (1) summary
      COG5070
      Location:104 → 243
      VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

    15. XM_006526054.5 → XP_006526117.1  transmembrane protein 241 isoform X6

      Conserved Domains (1) summary
      COG5070
      Location:104 → 243
      VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

    16. XM_006526051.5 → XP_006526114.1  transmembrane protein 241 isoform X1

      Conserved Domains (1) summary
      COG5070
      Location:104 → 243
      VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

    17. XM_006526052.5 → XP_006526115.1  transmembrane protein 241 isoform X2

      Conserved Domains (1) summary
      COG5070
      Location:104 → 243
      VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

    18. XM_006526060.5 → XP_006526123.1  transmembrane protein 241 isoform X14

      Conserved Domains (1) summary
      COG5070
      Location:10 → 167
      VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

    19. XM_006526058.5 → XP_006526121.1  transmembrane protein 241 isoform X10

      Conserved Domains (1) summary
      COG5070
      Location:10 → 193
      VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

    20. XM_036161190.1 → XP_036017083.1  transmembrane protein 241 isoform X4

    21. XM_036161189.1 → XP_036017082.1  transmembrane protein 241 isoform X3

    22. XM_011246966.4 → XP_011245268.1  transmembrane protein 241 isoform X15

      Conserved Domains (1) summary
      COG5070
      Location:21 → 142
      VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

    23. XM_011246965.2 → XP_011245267.1  transmembrane protein 241 isoform X12

      Conserved Domains (1) summary
      COG5070
      Location:53 → 192
      VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

    24. XM_030250520.2 → XP_030106380.1  transmembrane protein 241 isoform X26

      Conserved Domains (1) summary
      COG5070
      Location:10 → 167
      VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

    25. XM_036161195.1 → XP_036017088.1  transmembrane protein 241 isoform X23

      Related
      ENSMUSP00000089709.5, ENSMUST00000092075.5
      Conserved Domains (1) summary
      COG5070
      Location:10 → 193
      VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

    26. XM_006526063.5 → XP_006526126.1  transmembrane protein 241 isoform X20

      Conserved Domains (1) summary
      COG5070
      Location:104 → 243
      VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

    27. XM_011246968.4 → XP_011245270.1  transmembrane protein 241 isoform X24

    RNA

    1. XR_003952532.2 RNA Sequence

    2. XR_003952529.2 RNA Sequence

    3. XR_003952530.2 RNA Sequence

    4. XR_004939867.1 RNA Sequence

    5. XR_003952533.2 RNA Sequence

    6. XR_386003.5 RNA Sequence

    7. XR_386002.5 RNA Sequence

    8. XR_386001.5 RNA Sequence

    9. XR_386000.5 RNA Sequence

    10. XR_004939869.1 RNA Sequence

    11. XR_004939868.1 RNA Sequence

    12. XR_004939870.1 RNA Sequence

    13. XR_004939871.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UME2.2 GenPept UniProtKB/Swiss-Prot:Q3UME2

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