U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    wg wingless [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34009, updated on 9-Dec-2024

    Summary

    Official Symbol
    wgprovided by FlyBase
    Official Full Name
    winglessprovided by FlyBase
    Primary source
    FLYBASE:FBgn0284084
    Locus tag
    Dmel_CG4889
    See related
    AllianceGenome:FB:FBgn0284084
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Br; CG4889; D.int-1; Dint-1; Dm Wg; Dm-1; Dmel\CG4889; DWint-1; dWnt; Dwnt-1; DWnt-1; fg; Gla; I; int-1; l(2)02657; l(2)rO727; l(2)SH1281; l(2)SH2 1281; l(2)wg; Sp; spd; Wg; WG; wgl; wnt; Wnt; WNT; Wnt-1; wnt1; Wnt1
    Summary
    Enables several functions, including glycosaminoglycan binding activity; heparan sulfate proteoglycan binding activity; and signaling receptor binding activity. Involved in several processes, including Malpighian tubule development; open tracheal system development; and regionalization. Located in several cellular components, including membrane raft; multivesicular body; and terminal bouton. Colocalizes with early endosome and late endosome. Is expressed in several structures, including anterior-posterior subdivision of organism; epithelium; gut section; larval imaginal tissue; and somatic precursor cell. Used to study obesity. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 15. Orthologous to human WNT1 (Wnt family member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    27F1-27F1; 2-26 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7307159..7316265)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7307159..7316265)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Wnt oncogene analog 4 Neighboring gene long non-coding RNA:CR45304 Neighboring gene Wnt oncogene analog 6

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables extracellular matrix binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables frizzled binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables frizzled binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables frizzled binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables glycosaminoglycan binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heparan sulfate proteoglycan binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables morphogen activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables morphogen activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor ligand activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables receptor ligand activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Malpighian tubule bud morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Malpighian tubule tip cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in anterior/posterior pattern specification, imaginal disc IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in branch fusion, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in branching morphogenesis of an epithelial tube IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cardioblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell elongation involved in imaginal disc-derived wing morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chitin-based larval cuticle pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in compound eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in determination of genital disc primordium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in digestive tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dorsal closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dorsal/ventral pattern formation, imaginal disc IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ectoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in epidermis development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in epithelial cell proliferation involved in Malpighian tubule morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in epithelial cell type specification, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in follicle cell of egg chamber development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in genital disc anterior/posterior pattern formation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in genital disc sexually dimorphic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hindgut morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in histoblast morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in imaginal disc development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in imaginal disc-derived wing margin morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in imaginal disc-derived wing margin morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in labial disc development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in larval lymph gland hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in larval visceral muscle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lymph gland crystal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lymph gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mesoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mesoderm morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of hemocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuroblast development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in pericardial nephrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of compound eye retinal cell programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of crystal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of imaginal disc growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of positive regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in posterior Malpighian tubule development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proboscis development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of compound eye pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in segment polarity determination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spiracle morphogenesis, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in tissue regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ventral midline development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in wing cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in wing disc development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in multivesicular body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in terminal bouton IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    wingless
    Names
    CG4889-PA
    Wg
    Wnt-1
    bristled
    complementation group I
    flag
    glazed
    lethal (2) SH1281
    spade
    sternopleural
    wg-PA

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7307159..7316265
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078778.5NP_523502.1  wingless [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523502.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P09615, Q27768, Q27769, Q8IPI1, Q8MQP9, Q9VM27
      UniProtKB/TrEMBL
      I1WYH9
      Related
      FBpp0079060
      Conserved Domains (1) summary
      cd19333
      Location:64468
      Wnt_Wnt1; Wnt domain found in proto-oncogene Wnt-1 and similar proteins