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    Mdh1 Malate dehydrogenase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34414, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mdh1provided by FlyBase
    Official Full Name
    Malate dehydrogenase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0262782
    Locus tag
    Dmel_CG5362
    See related
    AllianceGenome:FB:FBgn0262782
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5362; cMdh; CT17038; Dmel\CG5362; Mdh; MDH; Mdh-1; MDH-1; MDH1; Mdh2; MdhD; Q9VKX2; sMdh
    Summary
    Enables L-malate dehydrogenase (NAD+) activity. Involved in NADH metabolic process; malate metabolic process; and oxaloacetate metabolic process. Located in cytosol. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 88. Orthologous to human MDH1 (malate dehydrogenase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Mdh1 in Genome Data Viewer
    Location:
    31E1-31E1; 2-42 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10393774..10396332, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10393774..10396332, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S7 Neighboring gene daughterless Neighboring gene antisense RNA:CR45789 Neighboring gene CCR4-NOT transcription complex subunit 4 Neighboring gene uncharacterized protein Neighboring gene Like Sm protein 4 Neighboring gene Ionotropic receptor 31a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparative analysis of malate dehydrogenases of Drosophila melanogaster. O'Brien SJ. Biochem Genet, 1973 Oct. PMID 4201525
    2. Purification and properties of Drosophila malate dehydrogenases. McReynolds MS, et al. Biochim Biophys Acta, 1970 Feb 11. PMID 4313528
    3. Biochemical studies of supernatant malate dehydrogenase allozymes in Drosophila melanogaster. Alahiotis S. Comp Biochem Physiol B, 1979. PMID 45555
    4. Isozyme variability in species of the genus Drosophila. VII. Genotype-environment relationships in populations of D. melanogaster from the Eastern United States. Johnson FM, et al. Biochem Genet, 1973 Oct. PMID 4201524
    5. Ecdysone-modulated response of Drosophila cytosolic malate dehydrogenase to juvenile hormone. Farkas R, et al. Arch Insect Biochem Physiol, 1997. PMID 9131782

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-malate dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-malate dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-malate dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NADH metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NADH metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in gluconeogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in malate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in malate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in malate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in malate-aspartate shuttle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in oxaloacetate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oxaloacetate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    malate dehydrogenase 1
    Names
    CG5362-PA
    CG5362-PB
    Mdh1-PA
    Mdh1-PB
    cytoplasmic Mdh
    cytosolic malate dehydrogenase
    malate dehydrogenase
    malic DH
    NP_001285803.1
    NP_609394.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10393774..10396332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298874.1 → NP_001285803.1  malate dehydrogenase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285803.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQS7, Q9VKX2
      Conserved Domains (2) summary
      TIGR01758
      Location:6 → 328
      MDH_euk_cyt; malate dehydrogenase, NAD-dependent
      cd01336
      Location:3 → 327
      MDH_cytoplasmic_cytosolic; Cytoplasmic and cytosolic Malate dehydrogenases

    2. NM_135550.2 → NP_609394.1  malate dehydrogenase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609394.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQS7, Q9VKX2
      Related
      FBpp0079640
      Conserved Domains (2) summary
      TIGR01758
      Location:6 → 328
      MDH_euk_cyt; malate dehydrogenase, NAD-dependent
      cd01336
      Location:3 → 327
      MDH_cytoplasmic_cytosolic; Cytoplasmic and cytosolic Malate dehydrogenases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MQS7 Q8MQS7
    Q9VKX2 Q9VKX2

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