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    CD200R1L CD200 receptor 1 like [ Homo sapiens (human) ]

    Gene ID: 344807, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CD200R1Lprovided by HGNC
    Official Full Name
    CD200 receptor 1 likeprovided by HGNC
    Primary source
    HGNC:HGNC:24665
    See related
    Ensembl:ENSG00000206531 AllianceGenome:HGNC:24665
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD200R2; CD200RLa
    Summary
    Predicted to enable signaling receptor activity. Predicted to be involved in regulation of neuroinflammatory response. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
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    Genomic context

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    See CD200R1L in Genome Data Viewer
    Location:
    3q13.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (112815711..112846864, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (115536646..115567808, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (112534558..112565711, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene MAT2A pseudogene 1 Neighboring gene NANOG hESC enhancer GRCh37_chr3:112463594-112464448 Neighboring gene long intergenic non-protein coding RNA 2042 Neighboring gene microRNA 9900 Neighboring gene Sharpr-MPRA regulatory region 12929 Neighboring gene CD200R1L antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:112543386-112543886 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:112563646-112563805 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_64395 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:112590118-112590618 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:112603434-112604024 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:112604025-112604615 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:112612841-112614040 Neighboring gene CD200R1 pseudogene 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_64462 Neighboring gene CD200 receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. CD200R1L is a functional evolutionary conserved activating receptor in human neutrophils. Pascoal Ramos MI, et al. J Leukoc Biol, 2022 Feb. PMID 33884657, Free PMC Article
    2. Is the CD200/CD200 receptor interaction more than just a myeloid cell inhibitory signal? Minas K, et al. Crit Rev Immunol, 2006. PMID 16928187, Free PMC Article
    3. CD200 receptor family members represent novel DAP12-associated activating receptors on basophils and mast cells. Voehringer D, et al. J Biol Chem, 2004 Dec 24. PMID 15471863
    4. Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. Wright GJ, et al. J Immunol, 2003 Sep 15. PMID 12960329
    5. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. Tao S, et al. Carcinogenesis, 2012 Mar. PMID 22219177, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of neuroinflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cell surface glycoprotein CD200 receptor 2
    Names
    CD200 cell surface glycoprotein receptor 2
    CD200 cell surface glycoprotein receptor-like 2
    CD200 cell surface glycoprotein receptor-like a
    CD200 receptor 2
    CD200 receptor-like 2
    cell surface glycoprotein CD200 receptor 1-like
    cell surface glycoprotein OX2 receptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008784.4 → NP_001008784.2  cell surface glycoprotein CD200 receptor 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001008784.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, coding) represents the allele encoded by the GRCh38 reference genome and encodes isoform (1).
      Source sequence(s)
      AC074044, AC092892
      Consensus CDS
      CCDS43131.1
      UniProtKB/Swiss-Prot
      Q6Q8B3, Q6WHB7
      Related
      ENSP00000381272.1, ENST00000398214.5
      Conserved Domains (1) summary
      cl11960
      Location:156 → 224
      Ig; Immunoglobulin domain

    2. NM_001199215.3 → NP_001186144.1  cell surface glycoprotein CD200 receptor 2 isoform 2

      See identical proteins and their annotated locations for NP_001186144.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2, coding) represents the allele encoded by the GRCh38 reference genome and encodes isoform (2).
      Source sequence(s)
      AC074044, AC092892
      Consensus CDS
      CCDS56267.1
      Related
      ENSP00000418413.1, ENST00000488794.6
      Conserved Domains (1) summary
      cl11960
      Location:135 → 203
      Ig; Immunoglobulin domain

    3. NM_001370552.3 → NP_001357481.1  cell surface glycoprotein CD200 receptor 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3, coding) represents the allele encoded by the GRCh38 reference genome and encodes isoform (2).
      Source sequence(s)
      AC074044, AC092892
      Consensus CDS
      CCDS56267.1
      Conserved Domains (1) summary
      cl11960
      Location:135 → 203
      Ig; Immunoglobulin domain

    RNA

    1. NR_178042.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, non-coding) uses the same exon combination as variant (1, coding) but represents the allele present on the T2T-CHM13v2.0 genome assembly. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      CP068275

    2. NR_178043.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2, non-coding) uses the same exon combination as variant (2, coding) but represents the allele present on the T2T-CHM13v2.0 genome assembly. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      CP068275

    3. NR_178044.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3, non-coding) uses the same exon combination as variant (3, coding) but represents the allele present on the T2T-CHM13v2.0 genome assembly. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      CP068275

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      112815711..112846864 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      115536646..115567808 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6Q8B3.2 GenPept UniProtKB/Swiss-Prot:Q6Q8B3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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