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    spz4 spatzle 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34572, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spz4provided by FlyBase
    Official Full Name
    spatzle 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0032362
    Locus tag
    Dmel_CG14928
    See related
    AllianceGenome:FB:FBgn0032362
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14928; CT34755; Dmel\CG14928; Spz-4; Spz4
    Summary
    Predicted to enable Toll binding activity and growth factor activity. Predicted to be involved in central nervous system formation and innate immune response. Located in extracellular space. Is expressed in organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See spz4 in Genome Data Viewer
    Location:
    32F2-32F2; 2-44 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11501715..11508649)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11501715..11508649)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene spalt-adjacent Neighboring gene Component of oligomeric golgi complex 8 Neighboring gene Discs large 5 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ex vivo genome-wide RNAi screening of the Drosophila Toll signaling pathway elicited by a larva-derived tissue extract. Kanoh H, et al. Biochem Biophys Res Commun, 2015 Nov 13. PMID 26427875
    2. A family of proteins related to Spätzle, the toll receptor ligand, are encoded in the Drosophila genome. Parker JS, et al. Proteins, 2001 Oct 1. PMID 11536362
    3. Evolutionary and functional epitopes of the Spätzle protein: new insights into activation of the Toll receptor. Wang Y, et al. Cell Mol Life Sci, 2009 May. PMID 19308321, Free PMC Article
    4. Large-Scale Transgenic Drosophila Resource Collections for Loss- and Gain-of-Function Studies. Zirin J, et al. Genetics, 2020 Apr. PMID 32071193, Free PMC Article
    5. Drosophila neurotrophins reveal a common mechanism for nervous system formation. Zhu B, et al. PLoS Biol, 2008 Nov 18. PMID 19018662, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Toll binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in central nervous system formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    spatzle 4
    Names
    CG14928-PB
    spatzle4
    spz4-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      11501715..11508649
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135660.3 → NP_609504.2  spatzle 4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609504.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D0IQH0, Q9VKG9
      Conserved Domains (1) summary
      pfam16077
      Location:448 → 536
      Spaetzle; Spaetzle
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKG9.2 Q9VKG9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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