oxt oxytocin [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: oxtprovided by ZNC
Official Full Name: oxytocinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030407-1
See related: Ensembl:ENSDARG00000042845 AllianceGenome:ZFIN:ZDB-GENE-030407-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ist; itnp; oxtl; IT-NP; fj33a01; wu:fj33a01; wu:fq40d10
Summary: Predicted to enable neuropeptide hormone activity. Acts upstream of or within with a positive effect on swimming behavior. Acts upstream of or within monoatomic ion homeostasis. Predicted to be located in extracellular region. Predicted to be active in extracellular space and secretory granule. Is expressed in several structures, including digestive system; female organism; male organism; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in diabetes insipidus and neurohypophyseal diabetes insipidus. Orthologous to several human genes including OXT (oxytocin/neurophysin I prepropeptide). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (72087619..72093255)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (71303113..71308749)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Developmental Effects of Oxytocin Neurons on Social Affiliation and Processing of Social Information.
Title: Developmental Effects of Oxytocin Neurons on Social Affiliation and Processing of Social Information.
These results showed that TRPV4 modulates ion balance through the isotocin pathway.
Title: Transient receptor potential vanilloid 4 modulates ion balance through the isotocin pathway in zebrafish (Danio rerio).
Genetic loss of roundabout homolog 2 protein (robo2)displayed decreased synaptic oxytocin (OXT) content and robo2 mutants displayed reduced mobility of the actin probe Lifeact-EGFP in OXT synapses.
Title: Robo2 regulates synaptic oxytocin content by affecting actin dynamics.
Isotocin stimulates the proliferation of epidermal stem cells and differentiation of ionocyte progenitors by regulating the P63 and Foxi3a transcription factors, consequently enhancing the functional activities of ionocytes.
Title: Isotocin controls ion regulation through regulating ionocyte progenitor differentiation and proliferation.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables neurohypophyseal hormone activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within monoatomic ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect swimming behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: oxytocin-neurophysin 1

Names: isotocin neurophysin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.