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    cdgs-1 Phosphatidate cytidylyltransferase [ Caenorhabditis elegans ]

    Gene ID: 3565046, updated on 2-Nov-2024

    Summary

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    Official Symbol
    cdgs-1
    Official Full Name
    Phosphatidate cytidylyltransferase
    Primary source
    WormBase:WBGene00016384
    Locus tag
    CELE_C33H5.18
    See related
    AllianceGenome:WB:WBGene00016384
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphatidate cytidylyltransferase activity. Predicted to be involved in CDP-diacylglycerol biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including intestine; nervous system; non-striated muscle; pharynx; and tail. Orthologous to human CDS1 (CDP-diacylglycerol synthase 1) and CDS2 (CDP-diacylglycerol synthase 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See cdgs-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (7812908..7815733, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Methyltransferase FkbM domain-containing protein Neighboring gene Zinc finger CCCH-type with G patch domain-containing protein Neighboring gene ncRNA Neighboring gene Resistance to inhibitors of cholinesterase protein 3 Neighboring gene MS Related Protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of PLC-mediated signalling in vivo by CDP-diacylglycerol synthase. Wu L, et al. Nature, 1995 Jan 19. PMID 7816135
    2. Spatial control of phospholipid flux restricts endoplasmic reticulum sheet formation to allow nuclear envelope breakdown. Bahmanyar S, et al. Genes Dev, 2014 Jan 15. PMID 24449268, Free PMC Article
    3. Intracellular lipid surveillance by small G protein geranylgeranylation. Watterson A, et al. Nature, 2022 May. PMID 35585236, Free PMC Article
    4. Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans. Gottschalk A, et al. EMBO J, 2005 Jul 20. PMID 15990870, Free PMC Article
    5. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidate cytidylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CDP-diacylglycerol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Phosphatidate cytidylyltransferase
    NP_501297.1
    • Confirmed by transcript evidence
    NP_501298.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7812908..7815733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068897.5 → NP_501298.1  Phosphatidate cytidylyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501298.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G8JY50, P53439
      Conserved Domains (1) summary
      cl21502
      Location:147 → 443
      CTP_transf_1; Cytidylyltransferase family

    2. NM_068896.7 → NP_501297.1  Phosphatidate cytidylyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501297.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P53439
      Conserved Domains (1) summary
      cl21502
      Location:137 → 433
      CTP_transf_1; Cytidylyltransferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53439.2

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