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    kin-1 Protein kinase domain-containing protein;cAMP-dependent protein kinase catalytic subunit [ Caenorhabditis elegans ]

    Gene ID: 3565407, updated on 9-Dec-2024

    Summary

    Official Symbol
    kin-1
    Official Full Name
    Protein kinase domain-containing protein;cAMP-dependent protein kinase catalytic subunit
    Primary source
    WormBase:WBGene00002189
    Locus tag
    CELE_ZK909.2
    See related
    AllianceGenome:WB:WBGene00002189
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables cAMP-dependent protein kinase activity. Involved in positive regulation of oocyte maturation. Predicted to be part of cAMP-dependent protein kinase complex. Predicted to be active in cytosol and nucleus. Is expressed in body wall musculature; excretory cell; gonad; intestine; and nervous system. Human ortholog(s) of this gene implicated in adrenal cortical adenoma; congestive heart failure; fibrolamellar carcinoma; platelet-type bleeding disorder 19; and primary pigmented nodular adrenocortical disease 4. Orthologous to several human genes including PRKACA (protein kinase cAMP-activated catalytic subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See kin-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    17
    Sequence:
    Chromosome: I; NC_003279.8 (14913766..14952226)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene SSD domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 Neighboring gene F-box associated domain-containing protein

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cAMP-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cAMP-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cAMP-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cyclic nucleotide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of oocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of cAMP-dependent protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cAMP-dependent protein kinase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    Protein kinase domain-containing protein;cAMP-dependent protein kinase catalytic subunit
    NP_001366905.1
    • Confirmed by transcript evidence
    NP_001367021.1
    • Confirmed by transcript evidence
    NP_001367022.1
    • Partially confirmed by transcript evidence
    NP_001367023.1
    • Confirmed by transcript evidence
    NP_001367024.1
    • Confirmed by transcript evidence
    NP_001367025.1
    • Partially confirmed by transcript evidence
    NP_001368699.1
    • Confirmed by transcript evidence
    NP_493605.1
    • Confirmed by transcript evidence
    NP_740954.1
    • Confirmed by transcript evidence
    NP_740956.1
    • Confirmed by transcript evidence
    NP_740958.1
    • Partially confirmed by transcript evidence
    NP_740960.1
    • Partially confirmed by transcript evidence
    NP_740961.1
    • Partially confirmed by transcript evidence
    NP_740962.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      14913766..14952226
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001381269.1NP_001368699.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2X0T496
      Conserved Domains (1) summary
      cd14209
      Location:254556
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
    2. NM_170958.6NP_740954.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740954.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P21137
      Conserved Domains (2) summary
      PTZ00263
      Location:71381
      PTZ00263; protein kinase A catalytic subunit; Provisional
      cd14209
      Location:72361
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
    3. NM_001381270.1NP_001367024.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd14209
      Location:72374
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
    4. NM_170960.7NP_740956.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740956.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P21137
      Conserved Domains (2) summary
      PTZ00263
      Location:33343
      PTZ00263; protein kinase A catalytic subunit; Provisional
      cd14209
      Location:34323
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
    5. NM_001381271.1NP_001367023.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd14209
      Location:34336
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
    6. NM_061204.4NP_493605.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493605.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P21137
      Conserved Domains (2) summary
      PTZ00263
      Location:49359
      PTZ00263; protein kinase A catalytic subunit; Provisional
      cd14209
      Location:50339
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
    7. NM_001381272.1NP_001366905.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd14209
      Location:50352
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
    8. NM_170962.5NP_740958.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740958.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P21137
      Conserved Domains (2) summary
      PTZ00263
      Location:60370
      PTZ00263; protein kinase A catalytic subunit; Provisional
      cd14209
      Location:61350
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
    9. NM_001381273.1NP_001367025.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd14209
      Location:61363
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
    10. NM_170965.3NP_740961.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740961.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18310, O18311, P21137, Q9UB39, Q9XZP8, Q9XZP9, Q9XZQ0, Q9XZQ8, Q9XZQ9
      Conserved Domains (1) summary
      cd14209
      Location:79381
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
    11. NM_170964.6NP_740960.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740960.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P21137
      Conserved Domains (2) summary
      PTZ00263
      Location:78388
      PTZ00263; protein kinase A catalytic subunit; Provisional
      cd14209
      Location:79368
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
    12. NM_170966.3NP_740962.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740962.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P21137
      Conserved Domains (2) summary
      PTZ00263
      Location:39349
      PTZ00263; protein kinase A catalytic subunit; Provisional
      cd14209
      Location:40329
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
    13. NM_001381274.1NP_001367022.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd14209
      Location:40342
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
    14. NM_001381275.2NP_001367021.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd14209
      Location:274545
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase