U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    kin-1 Protein kinase domain-containing protein;cAMP-dependent protein kinase catalytic subunit [ Caenorhabditis elegans ]

    Gene ID: 3565407, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    kin-1
    Official Full Name
    Protein kinase domain-containing protein;cAMP-dependent protein kinase catalytic subunit
    Primary source
    WormBase:WBGene00002189
    Locus tag
    CELE_ZK909.2
    See related
    AllianceGenome:WB:WBGene00002189
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables cAMP-dependent protein kinase activity. Involved in positive regulation of oocyte maturation. Predicted to be part of cAMP-dependent protein kinase complex. Predicted to be active in cytosol and nucleus. Is expressed in body wall musculature; excretory cell; gonad; intestine; and nervous system. Human ortholog(s) of this gene implicated in adrenal cortical adenoma; congestive heart failure; fibrolamellar carcinoma; platelet-type bleeding disorder 19; and primary pigmented nodular adrenocortical disease 4. Orthologous to several human genes including PRKACA (protein kinase cAMP-activated catalytic subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See kin-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    17
    Sequence:
    Chromosome: I; NC_003279.8 (14913766..14952226)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene SSD domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 Neighboring gene F-box associated domain-containing protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Cloning, characterization, and expression of the gene for the catalytic subunit of cAMP-dependent protein kinase in Caenorhabditis elegans. Identification of highly conserved and unique isoforms generated by alternative splicing. Gross RE, et al. J Biol Chem, 1990 Apr 25. PMID 2324104
    2. N-Myristoylation of the catalytic subunit of cAMP-dependent protein kinase in the free-living nematode Caenorhabditis elegans. Aspbury RA, et al. Biochem Biophys Res Commun, 1997 Sep 18. PMID 9299544
    3. Expression of multiple isoforms of the cAMP-dependent protein kinase (PK-A) catalytic subunit in the nematode, Caenorhabditis elegans. Bowen LC, et al. Cell Signal, 2006 Dec. PMID 16806821
    4. siRNA-mediated knockdown of a splice variant of the PK-A catalytic subunit gene causes adult-onset paralysis in C. elegans. Murray P, et al. Gene, 2008 Jan 31. PMID 18077108
    5. Characterisation of the N'1 isoform of the cyclic AMP-dependent protein kinase (PK-A) catalytic subunit in the nematode, Caenorhabditis elegans. Clegg RA, et al. Arch Biochem Biophys, 2012 Mar 1. PMID 22286028

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Galpha/GSA-1 works upstream of PKA/KIN-1 to regulate calcium signaling and contractility in the Caenorhabditis elegans spermatheca.
      Title: Gα/GSA-1 works upstream of PKA/KIN-1 to regulate calcium signaling and contractility in the Caenorhabditis elegans spermatheca.
    2. this study shows that PKA/KIN-1 mediates innate immune responses to bacterial pathogens
      Title: PKA/KIN-1 mediates innate immune responses to bacterial pathogens in Caenorhabditis elegans.
    3. we identified TWK-7 as a putative downstream target of the GalphaS-KIN-1/PKA pathway at the level of the gamma-aminobutyric acid (GABA)ergic D-type motor neurons. Due to this epistatic interaction, we suggest that KIN-1/PKA and TWK-7 may share a common pathway that is probably involved in the modulation of both locomotor activity and locomotion behavior during forward crawling.
      Title: Locomotion Behavior Is Affected by the Gα(S) Pathway and the Two-Pore-Domain K(+) Channel TWK-7 Interacting in GABAergic Motor Neurons in Caenorhabditis elegans.
    4. Thus, our results suggest that PKA(KIN-1) activates neurons during a rhythmic behavior by promoting presynaptic calcium influx through specific voltage-gated calcium channels
      Title: PKA controls calcium influx into motor neurons during a rhythmic behavior.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cAMP-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cAMP-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cAMP-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclic nucleotide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of oocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of cAMP-dependent protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cAMP-dependent protein kinase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Protein kinase domain-containing protein;cAMP-dependent protein kinase catalytic subunit
    NP_001366905.1
    • Confirmed by transcript evidence
    NP_001367021.1
    • Confirmed by transcript evidence
    NP_001367022.1
    • Partially confirmed by transcript evidence
    NP_001367023.1
    • Confirmed by transcript evidence
    NP_001367024.1
    • Confirmed by transcript evidence
    NP_001367025.1
    • Partially confirmed by transcript evidence
    NP_001368699.1
    • Confirmed by transcript evidence
    NP_493605.1
    • Confirmed by transcript evidence
    NP_740954.1
    • Confirmed by transcript evidence
    NP_740956.1
    • Confirmed by transcript evidence
    NP_740958.1
    • Partially confirmed by transcript evidence
    NP_740960.1
    • Partially confirmed by transcript evidence
    NP_740961.1
    • Partially confirmed by transcript evidence
    NP_740962.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      14913766..14952226
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001381269.1 → NP_001368699.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2X0T496
      Conserved Domains (1) summary
      cd14209
      Location:254 → 556
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    2. NM_170958.6 → NP_740954.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740954.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P21137
      Conserved Domains (2) summary
      PTZ00263
      Location:71 → 381
      PTZ00263; protein kinase A catalytic subunit; Provisional
      cd14209
      Location:72 → 361
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    3. NM_001381270.1 → NP_001367024.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd14209
      Location:72 → 374
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    4. NM_170960.7 → NP_740956.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740956.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P21137
      Conserved Domains (2) summary
      PTZ00263
      Location:33 → 343
      PTZ00263; protein kinase A catalytic subunit; Provisional
      cd14209
      Location:34 → 323
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    5. NM_001381271.1 → NP_001367023.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd14209
      Location:34 → 336
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    6. NM_061204.4 → NP_493605.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493605.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P21137
      Conserved Domains (2) summary
      PTZ00263
      Location:49 → 359
      PTZ00263; protein kinase A catalytic subunit; Provisional
      cd14209
      Location:50 → 339
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    7. NM_001381272.1 → NP_001366905.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd14209
      Location:50 → 352
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    8. NM_170962.5 → NP_740958.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740958.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P21137
      Conserved Domains (2) summary
      PTZ00263
      Location:60 → 370
      PTZ00263; protein kinase A catalytic subunit; Provisional
      cd14209
      Location:61 → 350
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    9. NM_001381273.1 → NP_001367025.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd14209
      Location:61 → 363
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    10. NM_170965.3 → NP_740961.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740961.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18310, O18311, P21137, Q9UB39, Q9XZP8, Q9XZP9, Q9XZQ0, Q9XZQ8, Q9XZQ9
      Conserved Domains (1) summary
      cd14209
      Location:79 → 381
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    11. NM_170964.6 → NP_740960.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740960.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P21137
      Conserved Domains (2) summary
      PTZ00263
      Location:78 → 388
      PTZ00263; protein kinase A catalytic subunit; Provisional
      cd14209
      Location:79 → 368
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    12. NM_170966.3 → NP_740962.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740962.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P21137
      Conserved Domains (2) summary
      PTZ00263
      Location:39 → 349
      PTZ00263; protein kinase A catalytic subunit; Provisional
      cd14209
      Location:40 → 329
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    13. NM_001381274.1 → NP_001367022.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd14209
      Location:40 → 342
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    14. NM_001381275.2 → NP_001367021.1  cAMP-dependent protein kinase catalytic subunit [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd14209
      Location:274 → 545
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21137.3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.