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    dip-2 AMP-dependent synthetase/ligase domain-containing protein;DMAP1-binding domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 3565539, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dip-2
    Official Full Name
    AMP-dependent synthetase/ligase domain-containing protein;DMAP1-binding domain-containing protein
    Primary source
    WormBase:WBGene00017885
    Locus tag
    CELE_F28B3.4
    See related
    AllianceGenome:WB:WBGene00017885
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Is expressed in hypodermal cell and neurons. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human DIP2A (disco interacting protein 2 homolog A); DIP2B (disco interacting protein 2 homolog B); and DIP2C (disco interacting protein 2 homolog C). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dip-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    18
    Sequence:
    Chromosome: I; NC_003279.8 (4934259..4949353)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Importin N-terminal domain-containing protein Neighboring gene Major Facilitator Superfamily Domain containing homolog Neighboring gene Phospholipid/glycerol acyltransferase domain-containing protein Neighboring gene Chloride channel protein CLC-d Neighboring gene Uncharacterized protein Neighboring gene Structural maintenance of chromosomes protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DIP-2 suppresses ectopic neurite sprouting and axonal regeneration in mature neurons. Noblett N, et al. J Cell Biol, 2019 Jan 7. PMID 30396999, Free PMC Article
    2. Increasing Complexity of the N-Glycome During Caenorhabditis Development. Wilson IBH, et al. Mol Cell Proteomics, 2023 Mar. PMID 36717059, Free PMC Article
    3. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DIP-2 suppresses ectopic neurite sprouting and axonal regeneration in mature neurons.
      Title: DIP-2 suppresses ectopic neurite sprouting and axonal regeneration in mature neurons.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    AMP-dependent synthetase/ligase domain-containing protein;DMAP1-binding domain-containing protein
    NP_001293298.1
    • Confirmed by transcript evidence
    NP_001293299.1
    • Confirmed by transcript evidence
    NP_001293301.1
    • Confirmed by transcript evidence
    NP_001293302.1
    • Confirmed by transcript evidence
    NP_001293304.1
    • Confirmed by transcript evidence
    NP_001293305.1
    • Confirmed by transcript evidence
    NP_001368484.1
    • Partially confirmed by transcript evidence
    NP_491483.4
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4934259..4949353
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306369.4 → NP_001293298.1  DMAP1-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293298.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AD00
      Conserved Domains (2) summary
      cd05905
      Location:1096 → 1677
      Dip2; Disco-interacting protein 2 (Dip2)
      pfam06464
      Location:4 → 114
      DMAP_binding; DMAP1-binding Domain

    2. NM_001306373.4 → NP_001293302.1  DMAP1-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293302.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AE78
      Conserved Domains (2) summary
      cd05905
      Location:1094 → 1675
      Dip2; Disco-interacting protein 2 (Dip2)
      pfam06464
      Location:4 → 114
      DMAP_binding; DMAP1-binding Domain

    3. NM_001306375.3 → NP_001293304.1  AMP-dependent synthetase/ligase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293304.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AJH3
      Conserved Domains (1) summary
      cd05905
      Location:1070 → 1651
      Dip2; Disco-interacting protein 2 (Dip2)

    4. NM_001306376.3 → NP_001293305.1  AMP-dependent synthetase/ligase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293305.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AL52
      Conserved Domains (1) summary
      cd05905
      Location:1068 → 1649
      Dip2; Disco-interacting protein 2 (Dip2)

    5. NM_001306372.4 → NP_001293301.1  AMP-dependent synthetase/ligase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293301.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AD24
      Conserved Domains (1) summary
      cd05905
      Location:954 → 1535
      Dip2; Disco-interacting protein 2 (Dip2)

    6. NM_001306370.3 → NP_001293299.1  AMP-dependent synthetase/ligase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293299.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AJG8
      Conserved Domains (1) summary
      cd05905
      Location:956 → 1537
      Dip2; Disco-interacting protein 2 (Dip2)

    7. NM_001379985.1 → NP_001368484.1  AMP-dependent synthetase/ligase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AL47
      Conserved Domains (1) summary
      cd05905
      Location:724 → 1305
      Dip2; Disco-interacting protein 2 (Dip2)

    8. NM_059082.7 → NP_491483.4  AMP-dependent synthetase/ligase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491483.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q1RS87
      Conserved Domains (1) summary
      cd05905
      Location:722 → 1303
      Dip2; Disco-interacting protein 2 (Dip2)
    Nucleotide Protein
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