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    Cul1 Cullin 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35742, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cul1provided by FlyBase
    Official Full Name
    Cullin 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0015509
    Locus tag
    Dmel_CG1877
    See related
    AllianceGenome:FB:FBgn0015509
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1877; cul-1; Cul-1; cul1; CUL1; Cullin-1; Cullin1; dCul-1; dCul1; dCUL1; dmCUL1; Dmel\CG1877; l(2)02074; l(2)k01207; lin 19; Lin-19; lin-19/cul-1; lin19; Lin19; lin19-like; Q9V312
    Summary
    Enables ubiquitin ligase complex scaffold activity. Involved in several processes, including negative regulation of signal transduction; positive regulation of neuron remodeling; and positive regulation of protein metabolic process. Located in nucleus. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; germline cell; imaginal disc; and mesoderm. Orthologous to human CUL1 (cullin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Cul1 in Genome Data Viewer
    Location:
    43F1-43F2; 2-57 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7916856..7921579)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3804361..3809084)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Autophagy-related 10 Neighboring gene Diacyl glycerol kinase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 43b Neighboring gene Lysine demethylase 4A Neighboring gene Major Facilitator Superfamily Transporter 12 Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class X

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding PubMed 
    enables protein-macromolecule adaptor activity  
    enables ubiquitin ligase complex scaffold activity PubMed 
    enables ubiquitin protein ligase binding  
    enables ubiquitin protein ligase binding  
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  
    involved_in negative regulation of antimicrobial peptide production PubMed 
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway PubMed 
    involved_in negative regulation of hippo signaling PubMed 
    involved_in negative regulation of insulin receptor signaling pathway PubMed 
    involved_in negative regulation of peptidoglycan recognition protein signaling pathway PubMed 
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in negative regulation of smoothened signaling pathway PubMed 
    involved_in negative regulation of smoothened signaling pathway PubMed 
    involved_in positive regulation of neuron remodeling PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process PubMed 
    involved_in positive regulation of protein ubiquitination PubMed 
    involved_in positive regulation of synaptonemal complex assembly PubMed 
    involved_in protein K11-linked ubiquitination PubMed 
    involved_in protein catabolic process PubMed 
    involved_in protein ubiquitination  
    involved_in protein ubiquitination PubMed 
    involved_in protein ubiquitination PubMed 
    involved_in ubiquitin-dependent protein catabolic process  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex  
    part_of SCF ubiquitin ligase complex PubMed 
    part_of SCF ubiquitin ligase complex PubMed 
    part_of cullin-RING ubiquitin ligase complex  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    cullin 1
    Names
    CG1877-PA
    CG1877-PB
    CG1877-PC
    CG1877-PD
    Cul1-PA
    Cul1-PB
    Cul1-PC
    Cul1-PD
    SCF-betaTrCP complex
    cullin
    cullin-1
    cullin1
    dCullin
    dCullin1
    lin-19-like
    lin19-like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7916856..7921579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165571.2 → NP_724623.1  cullin 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724623.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZ78, Q0E9G0, Q24311, Q9V312
      UniProtKB/TrEMBL
      D3DMX2
      Related
      FBpp0087921
      Conserved Domains (3) summary
      smart00182
      Location:454 → 593
      CULLIN; Cullin
      smart00884
      Location:701 → 765
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:21 → 669
      Cullin; Cullin family
    2. NM_165570.3 → NP_724622.1  cullin 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724622.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZ78, Q0E9G0, Q24311, Q9V312
      UniProtKB/TrEMBL
      D3DMX2
      Related
      FBpp0087922
      Conserved Domains (3) summary
      smart00182
      Location:454 → 593
      CULLIN; Cullin
      smart00884
      Location:701 → 765
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:21 → 669
      Cullin; Cullin family
    3. NM_165569.2 → NP_724621.1  cullin 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724621.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZ78, Q0E9G0, Q24311, Q9V312
      UniProtKB/TrEMBL
      D3DMX2
      Related
      FBpp0087923
      Conserved Domains (3) summary
      smart00182
      Location:454 → 593
      CULLIN; Cullin
      smart00884
      Location:701 → 765
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:21 → 669
      Cullin; Cullin family
    4. NM_078931.4 → NP_523655.1  cullin 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523655.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZ78, Q0E9G0, Q24311, Q9V312
      UniProtKB/TrEMBL
      D3DMX2
      Related
      FBpp0087924
      Conserved Domains (3) summary
      smart00182
      Location:454 → 593
      CULLIN; Cullin
      smart00884
      Location:701 → 765
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:21 → 669
      Cullin; Cullin family
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