ACC Acetyl-CoA carboxylase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ACCprovided by FlyBase
Official Full Name: Acetyl-CoA carboxylaseprovided by FlyBase
Primary source: FLYBASE:FBgn0033246
Locus tag: Dmel_CG11198
See related: AllianceGenome:FB:FBgn0033246
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: A1Z784_DROME; acc; Acc; ACoT; CG11198; CG8723; dACC; DmACC; Dmel\CG11198; FBgn0043811
Summary: Predicted to enable acetyl-CoA carboxylase activity and biotin carboxylase activity. Involved in cellular response to sucrose stimulus and triglyceride biosynthetic process. Located in cytoplasm. Is expressed in several structures, including adult head; adult heart; embryonic/larval fat body; embryonic/larval gut; and embryonic/larval oenocyte. Used to study chromosome 17q12 deletion syndrome. Orthologous to several human genes including ACACB (acetyl-CoA carboxylase beta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 44A1-44A2; 2-58 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (7974115..7991862, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (3861620..3879367, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ACC disruption in the oenocytes through RNA-interference induces lethality, as does oenocyte ablation.. this lethality is associated with a failure in the watertightness of the spiracles-the organs controlling the entry of air into the trachea.
Title: Drosophila melanogaster Acetyl-CoA-carboxylase sustains a fatty acid-dependent remote signal to waterproof the respiratory system.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0737 (e-PCR)
- UniSTS:61027

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables acetyl-CoA carboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetyl-CoA carboxylase activity	IEA Inferred from Electronic Annotation more info
enables acetyl-CoA carboxylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables biotin carboxylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acetyl-CoA metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to sucrose stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in response to sucrose	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Acetyl-CoA carboxylase

Names: ACC-PA; ACC-PB; ACC-PC; ACC-PE; ACC-PF; ACC-PG; CG11198-PA; CG11198-PB; CG11198-PC; CG11198-PE; CG11198-PF; CG11198-PG; aceto-acetyl-CoA-thiolase; acetyl CoA carboxylase; acetyl coenzyme A carboxylase; acetyl-CoA carboxylase; acetyl-CoA-carboxylase; acetyl-coenzyme A carboxylase; acyl-coA carboxylase

NP_001097226.1

EC 6.-.-.-

EC 6.3.4.14

EC 6.4.1.2

NP_001097227.2

EC 6.-.-.-

EC 6.3.4.14

EC 6.4.1.2

NP_001286177.1

EC 6.-.-.-

EC 6.3.4.14

EC 6.4.1.2

NP_001286178.1

EC 6.-.-.-

EC 6.3.4.14

EC 6.4.1.2

NP_610342.1

EC 6.-.-.-

EC 6.3.4.14

EC 6.4.1.2

NP_724636.1

EC 6.-.-.-

EC 6.3.4.14

EC 6.4.1.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

7974115..7991862 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001299249.1 → NP_001286178.1 Acetyl-CoA carboxylase, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286178.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JV23

Conserved Domains (7) summary

cd06850
Location:732 → 793

biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...

COG0439
Location:101 → 598

AccC; Biotin carboxylase [Lipid transport and metabolism]

pfam00289
Location:101 → 220

CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain

pfam01039
Location:1641 → 2185

Carboxyl_trans; Carboxyl transferase domain

pfam02785
Location:485 → 592

Biotin_carb_C; Biotin carboxylase C-terminal domain

pfam08326
Location:797 → 1541

ACC_central; Acetyl-CoA carboxylase, central region

cl17255
Location:225 → 448

ATP-grasp_4; ATP-grasp domain
NM_001299248.1 → NP_001286177.1 Acetyl-CoA carboxylase, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286177.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JV23

Conserved Domains (7) summary

cd06850
Location:732 → 793

biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...

COG0439
Location:101 → 598

AccC; Biotin carboxylase [Lipid transport and metabolism]

pfam00289
Location:101 → 220

CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain

pfam01039
Location:1641 → 2185

Carboxyl_trans; Carboxyl transferase domain

pfam02785
Location:485 → 592

Biotin_carb_C; Biotin carboxylase C-terminal domain

pfam08326
Location:797 → 1541

ACC_central; Acetyl-CoA carboxylase, central region

cl17255
Location:225 → 448

ATP-grasp_4; ATP-grasp domain
NM_165581.3 → NP_724636.1 Acetyl-CoA carboxylase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724636.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JV23

Related

FBpp0087948

Conserved Domains (7) summary

cd06850
Location:732 → 793

biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...

COG0439
Location:101 → 598

AccC; Biotin carboxylase [Lipid transport and metabolism]

pfam00289
Location:101 → 220

CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain

pfam01039
Location:1641 → 2185

Carboxyl_trans; Carboxyl transferase domain

pfam02785
Location:485 → 592

Biotin_carb_C; Biotin carboxylase C-terminal domain

pfam08326
Location:797 → 1541

ACC_central; Acetyl-CoA carboxylase, central region

cl17255
Location:225 → 448

ATP-grasp_4; ATP-grasp domain
NM_136498.3 → NP_610342.1 Acetyl-CoA carboxylase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_610342.1

Status: REVIEWED

UniProtKB/TrEMBL

A1Z784

Related

FBpp0087947

Conserved Domains (7) summary

cd06850
Location:891 → 952

biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...

COG0439
Location:260 → 757

AccC; Biotin carboxylase [Lipid transport and metabolism]

pfam00289
Location:260 → 379

CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain

pfam01039
Location:1800 → 2344

Carboxyl_trans; Carboxyl transferase domain

pfam02785
Location:644 → 751

Biotin_carb_C; Biotin carboxylase C-terminal domain

pfam08326
Location:956 → 1700

ACC_central; Acetyl-CoA carboxylase, central region

cl17255
Location:384 → 607

ATP-grasp_4; ATP-grasp domain
NM_001103756.3 → NP_001097226.1 Acetyl-CoA carboxylase, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097226.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JV23

Conserved Domains (7) summary

cd06850
Location:732 → 793

biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...

COG0439
Location:101 → 598

AccC; Biotin carboxylase [Lipid transport and metabolism]

pfam00289
Location:101 → 220

CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain

pfam01039
Location:1641 → 2185

Carboxyl_trans; Carboxyl transferase domain

pfam02785
Location:485 → 592

Biotin_carb_C; Biotin carboxylase C-terminal domain

pfam08326
Location:797 → 1541

ACC_central; Acetyl-CoA carboxylase, central region

cl17255
Location:225 → 448

ATP-grasp_4; ATP-grasp domain
NM_001103757.3 → NP_001097227.2 Acetyl-CoA carboxylase, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097227.2

Status: REVIEWED

UniProtKB/TrEMBL

A8DY67

Conserved Domains (7) summary

cd06850
Location:757 → 818

biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...

COG0439
Location:126 → 623

AccC; Biotin carboxylase [Lipid transport and metabolism]

pfam00289
Location:126 → 245

CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain

pfam01039
Location:1666 → 2210

Carboxyl_trans; Carboxyl transferase domain

pfam02785
Location:510 → 617

Biotin_carb_C; Biotin carboxylase C-terminal domain

pfam08326
Location:822 → 1566

ACC_central; Acetyl-CoA carboxylase, central region

cl17255
Location:250 → 473

ATP-grasp_4; ATP-grasp domain