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    Rad51D Rad51 recombinase D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35937, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rad51Dprovided by FlyBase
    Official Full Name
    Rad51 recombinase Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033389
    Locus tag
    Dmel_CG2412
    See related
    AllianceGenome:FB:FBgn0033389
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2412; Dm CG2412; Dmel\CG2412; dmRad51C; Rad51; Rad51C
    Summary
    Predicted to enable ATP-dependent DNA damage sensor activity; DNA strand exchange activity; and single-stranded DNA binding activity. Predicted to contribute to four-way junction DNA binding activity. Predicted to be involved in DNA metabolic process. Predicted to be part of Rad51B-Rad51C-Rad51D-XRCC2 complex. Predicted to be active in microtubule organizing center and replication fork. Human ortholog(s) of this gene implicated in hereditary breast ovarian cancer syndrome. Orthologous to human RAD51D (RAD51 paralog D). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Rad51D in Genome Data Viewer
    Location:
    45B1-45B1; 2-60 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9165632..9167670)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5053137..5055175)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44283 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Receptor mediated endocytosis 8 Neighboring gene Rab32 Neighboring gene long non-coding RNA:CR44284

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Epigenetic effect of the rad201(G1) mutation in a system with mobilization of nonautonomous P elements in Drosophila]. Khromykh IuM, et al. Genetika, 2008 Mar. PMID 18664138
    2. Persistent DNA damage signaling and DNA polymerase theta promote broken chromosome segregation. Clay DE, et al. J Cell Biol, 2021 Dec 6. PMID 34613334, Free PMC Article
    3. The Drosophila spn-D gene encodes a RAD51C-like protein that is required exclusively during meiosis. Abdu U, et al. Genetics, 2003 Sep. PMID 14504227, Free PMC Article
    4. Evolutionary dynamics of recently duplicated genes: Selective constraints on diverging paralogs in the Drosophila pseudoobscura genome. Meisel RP. J Mol Evol, 2009 Jul. PMID 19536449
    5. Evolutionary and functional analysis of the invariant SWIM domain in the conserved Shu2/SWS1 protein family from Saccharomyces cerevisiae to Homo sapiens. Godin SK, et al. Genetics, 2015 Apr. PMID 25659377, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP-dependent DNA damage sensor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP-dependent activity, acting on DNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA strand exchange activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    contributes_to four-way junction DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in DNA strand invasion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in telomere maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Rad51B-Rad51C-Rad51D-XRCC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in replication fork IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rad51 recombinase D
    Names
    CG2412-PB
    Rad51C
    Rad51D-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9165632..9167670
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136622.3 → NP_610466.2  Rad51 recombinase D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610466.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7R8, H0RNP1
      Conserved Domains (2) summary
      PRK09361
      Location:80 → 335
      radB; DNA repair and recombination protein RadB; Provisional
      cl21455
      Location:80 → 336
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z7R8 A1Z7R8

    Gene LinkOut

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