U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Nt5c 5' nucleotidase C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35984, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Nt5cprovided by FlyBase
    Official Full Name
    5' nucleotidase Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033426
    Locus tag
    Dmel_CG1814
    See related
    AllianceGenome:FB:FBgn0033426
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    45550393; 45551045; CG1814; Dmel\CG1814; dNT5C
    Summary
    Predicted to enable 5'-nucleotidase activity and single-stranded DNA binding activity. Predicted to be involved in DNA damage response. Predicted to be located in nucleus. Is expressed in several structures, including adult head; adult heart; larval muscle cell; and larval muscle system. Orthologous to human NT5DC2 (5'-nucleotidase domain containing 2) and NT5DC3 (5'-nucleotidase domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Nt5c in Genome Data Viewer
    Location:
    45F4-45F4; 2-61 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9577427..9581847)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5464932..5469352)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45281 Neighboring gene Odorant receptor 45b Neighboring gene Alkaline phosphatase 6 Neighboring gene Not1 Neighboring gene long non-coding RNA:CR46257 Neighboring gene SET and MYND domain containing, class 4, member 1 Neighboring gene uncharacterized protein Neighboring gene Uroporphyrinogen decarboxylase Neighboring gene Ribosomal protein L31 Neighboring gene closca

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Investigating cytosolic 5'-nucleotidase II family genes as candidates for neuropsychiatric disorders in Drosophila (114/150 chr). Singgih EL, et al. Transl Psychiatry, 2021 Jan 18. PMID 33462198, Free PMC Article
    2. Modifiers of notch transcriptional activity identified by genome-wide RNAi. Mourikis P, et al. BMC Dev Biol, 2010 Oct 19. PMID 20959007, Free PMC Article
    3. Expression of cardiac myosin-binding protein-C (cMyBP-C) in Drosophila as a model for the study of human cardiomyopathies. Vu Manh TP, et al. Hum Mol Genet, 2005 Jan 1. PMID 15525659
    4. Functional requirements of protein kinases and phosphatases in the development of the Drosophila melanogaster wing. Ostalé CM, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599799, Free PMC Article
    5. Proteomic Analysis of the Ubiquitin Landscape in the Drosophila Embryonic Nervous System and the Adult Photoreceptor Cells. Ramirez J, et al. PLoS One, 2015. PMID 26460970, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 5'-nucleotidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrial matrix ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    5' nucleotidase C
    Names
    CG1814-PA
    CG1814-PB
    CG1814-PC
    Nt5c-PA
    Nt5c-PB
    Nt5c-PC
    NP_610499.2
    NP_724800.1
    NP_724801.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9577427..9581847
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165680.2 → NP_724801.2  5' nucleotidase C, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724801.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7V8, C6SV33
      Related
      FBpp0087604
      Conserved Domains (1) summary
      pfam05761
      Location:22 → 457
      5_nucleotid; 5' nucleotidase family

    2. NM_136655.4 → NP_610499.2  5' nucleotidase C, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610499.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7V9, C6SV33
      Related
      FBpp0087605
      Conserved Domains (1) summary
      pfam05761
      Location:108 → 543
      5_nucleotid; 5' nucleotidase family

    3. NM_165679.3 → NP_724800.1  5' nucleotidase C, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724800.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6SV33, Q7K3S2
      Related
      FBpp0087606
      Conserved Domains (1) summary
      pfam05761
      Location:2 → 404
      5_nucleotid; 5' nucleotidase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z7V8 A1Z7V8
    A1Z7V9 A1Z7V9
    Q7K3S2 Q7K3S2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools