Nek6 NIMA-related kinase 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nek6provided by RGD
Official Full Name: NIMA-related kinase 6provided by RGD
Primary source: RGD:727779
See related: EnsemblRapid:ENSRNOG00000010897 AllianceGenome:RGD:727779
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protein serine/threonine kinase activity. Predicted to be involved in several processes, including positive regulation of canonical NF-kappaB signal transduction; protein phosphorylation; and regulation of mitotic metaphase/anaphase transition. Predicted to be located in centriolar satellite; cytosol; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Orthologous to human NEK6 (NIMA related kinase 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 69.4), Liver (RPKM 68.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q12

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (42693994..42766026)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (22284269..22356302)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (22811927..22888598)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH141371 (e-PCR)
- UniSTS:223367

RH144381 (e-PCR)
- UniSTS:233626

PMC128323P1 (e-PCR)
- UniSTS:270576

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables kinesin binding	IEA Inferred from Electronic Annotation more info
enables kinesin binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in chromosome segregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info	PubMed
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitotic metaphase/anaphase transition	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitotic metaphase/anaphase transition	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic metaphase/anaphase transition	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein kinase Nek6

Names: NIMA (never in mitosis gene a)-related expressed kinase 6; never in mitosis A-related kinase 6; nimA-related protein kinase 6

NP_001264161.1

EC 2.7.11.34

NP_891998.1

EC 2.7.11.34

XP_006234162.1

EC 2.7.11.34

XP_017447355.1

EC 2.7.11.34

XP_038961262.1

EC 2.7.11.34

XP_038961263.1

EC 2.7.11.34

XP_038961264.1

EC 2.7.11.34

XP_038961265.1

EC 2.7.11.34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001277232.1 → NP_001264161.1 serine/threonine-protein kinase Nek6

See identical proteins and their annotated locations for NP_001264161.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

BC160820, JAXUCZ010000003

UniProtKB/Swiss-Prot

P59895

UniProtKB/TrEMBL

A0A8L2R1R0, B1H218

Conserved Domains (1) summary

cd08224
Location:44 → 305

STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7
NM_182953.2 → NP_891998.1 serine/threonine-protein kinase Nek6

See identical proteins and their annotated locations for NP_891998.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

BC160820, JAXUCZ010000003

UniProtKB/Swiss-Prot

P59895

UniProtKB/TrEMBL

A0A8L2R1R0, B1H218

Related

ENSRNOP00000083098.1, ENSRNOT00000116855.2

Conserved Domains (1) summary

cd08224
Location:44 → 305

STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

42693994..42766026

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006234100.3 → XP_006234162.1 serine/threonine-protein kinase Nek6 isoform X1

See identical proteins and their annotated locations for XP_006234162.1

UniProtKB/Swiss-Prot

P59895

UniProtKB/TrEMBL

A0A8L2R1R0, B1H218

Conserved Domains (1) summary

cd08224
Location:44 → 305

STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7
XM_039105336.2 → XP_038961264.1 serine/threonine-protein kinase Nek6 isoform X1

UniProtKB/Swiss-Prot

P59895

UniProtKB/TrEMBL

A0A8L2R1R0, B1H218

Conserved Domains (1) summary

cd08224
Location:44 → 305

STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7
XM_039105335.2 → XP_038961263.1 serine/threonine-protein kinase Nek6 isoform X1

UniProtKB/Swiss-Prot

P59895

UniProtKB/TrEMBL

A0A8L2R1R0, B1H218

Conserved Domains (1) summary

cd08224
Location:44 → 305

STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7
XM_017591866.3 → XP_017447355.1 serine/threonine-protein kinase Nek6 isoform X1

UniProtKB/Swiss-Prot

P59895

UniProtKB/TrEMBL

A0A8L2R1R0, B1H218

Conserved Domains (1) summary

cd08224
Location:44 → 305

STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7
XM_039105337.2 → XP_038961265.1 serine/threonine-protein kinase Nek6 isoform X1

UniProtKB/Swiss-Prot

P59895

UniProtKB/TrEMBL

A0A8L2R1R0, B1H218

Related

ENSRNOP00000069207.2, ENSRNOT00000086147.3

Conserved Domains (1) summary

cd08224
Location:44 → 305

STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7
XM_039105334.2 → XP_038961262.1 serine/threonine-protein kinase Nek6 isoform X1

UniProtKB/Swiss-Prot

P59895

UniProtKB/TrEMBL

A0A8L2R1R0, B1H218

Conserved Domains (1) summary

cd08224
Location:44 → 305

STKc_Nek6_7; Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7