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    Prosalpha7 Proteasome alpha7 subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36018, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prosalpha7provided by FlyBase
    Official Full Name
    Proteasome alpha7 subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0023175
    Locus tag
    Dmel_CG1519
    See related
    AllianceGenome:FB:FBgn0023175
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    1519; alpha-7; Alpha-7; alpha7; Alpha7; alpha7_dm; CG1519; CPalpha7; Dmel\CG1519; Pros alpha7; prosalpha7; PROSalpha7; PSA3_DROME
    Summary
    Involved in follicle cell of egg chamber development and proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome core complex. Is expressed in adult head; adult heart; and organism. Used to study neurodegenerative disease. Orthologous to human PSMA3 (proteasome 20S subunit alpha 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Prosalpha7 in Genome Data Viewer
    Location:
    46B4-46B4; 2-61 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9846636..9847836, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5734141..5735341, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Mitochondrial amidoxime reducing component Neighboring gene Vesicle-associated membrane protein 7 Neighboring gene sting Neighboring gene Origin recognition complex subunit 6 Neighboring gene uncharacterized protein Neighboring gene Pyruvate carboxylase Neighboring gene antisense RNA:CR44293

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Argonaute2 turnover is regulated by the ubiquitin proteasome pathway. Chinen M, et al. Biochem Biophys Res Commun, 2017 Feb 12. PMID 28087276, Free PMC Article
    2. Isolation of natural products with anti-ageing activity from the fruits of Platanus orientalis. Chatzigeorgiou S, et al. Phytomedicine, 2017 Sep 15. PMID 28887920
    3. PI31 Is an Adaptor Protein for Proteasome Transport in Axons and Required for Synaptic Development. Liu K, et al. Dev Cell, 2019 Aug 19. PMID 31327739, Free PMC Article
    4. Diet-derived advanced glycation end products or lipofuscin disrupts proteostasis and reduces life span in Drosophila melanogaster. Tsakiri EN, et al. Free Radic Biol Med, 2013 Dec. PMID 23999505
    5. Overexpression of Dsk2/dUbqln results in severe developmental defects and lethality in Drosophila melanogaster that can be rescued by overexpression of the p54/Rpn10/S5a proteasomal subunit. Lipinszki Z, et al. FEBS J, 2011 Dec. PMID 21973017

    See all (108) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in follicle cell of egg chamber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome core complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    proteasome alpha7 subunit
    Names
    20S proteasome subunit alpha 7
    20S proteasome subunit alpha-7
    20s proteasome
    CG1519-PA
    Prosalpha7-PA
    alpha-subunit of 20S proteasome
    alpha7
    proteasome subunit alpha type-3
    proteosome alpha7 subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9846636..9847836 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165703.3 → NP_724834.1  proteasome alpha7 subunit [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724834.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O17313, Q8MKU6, Q9V5C6
      Related
      FBpp0089041
      Conserved Domains (2) summary
      COG0638
      Location:6 → 231
      PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
      cd03751
      Location:5 → 216
      proteasome_alpha_type_3; proteasome_alpha_type_3. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V5C6.1 Q9V5C6

    Gene LinkOut

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