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    CG12133 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36036, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG12133provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033469
    Locus tag
    Dmel_CG12133
    See related
    AllianceGenome:FB:FBgn0033469
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG12133; SP15
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in innate immune response and proteolysis. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG12133 in Genome Data Viewer
    Location:
    46C8-46C8; 2-61 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9967231..9968388)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5854736..5855893)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Pdrg1 prefoldin-like subunit Neighboring gene Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase 1 Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 3 subunit j Neighboring gene antisense RNA:CR46453 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Damage sensing mediated by serine proteases Hayan and Persephone for Toll pathway activation in apoptosis-deficient flies. Nakano S, et al. PLoS Genet, 2023 Jun. PMID 37319131, Free PMC Article
    2. Assessing the impact of comparative genomic sequence data on the functional annotation of the Drosophila genome. Bergman CM, et al. Genome Biol, 2002. PMID 12537575, Free PMC Article
    3. Serine proteases and their homologs in the Drosophila melanogaster genome: an initial analysis of sequence conservation and phylogenetic relationships. Ross J, et al. Gene, 2003 Jan 30. PMID 12568721
    4. Building a platform for predicting functions of serine protease-related proteins in Drosophila melanogaster and other insects. Cao X, et al. Insect Biochem Mol Biol, 2018 Dec. PMID 30367934, Free PMC Article
    5. A Superfamily-wide Activity Atlas of Serine Hydrolases in Drosophila melanogaster. Kumar K, et al. Biochemistry, 2021 Apr 27. PMID 33827210, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG12133-PB
    NP_610540.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9967231..9968388
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136696.2 → NP_610540.2  uncharacterized protein Dmel_CG12133 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610540.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z824
      Conserved Domains (2) summary
      smart00020
      Location:62 → 317
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:62 → 320
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z824 A1Z824

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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